It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …

Surface functionalization of metal nanoparticles (NPs), eg, using peptides and proteins, has
recently attracted a considerable attention in the field of design of therapeutics and …

Co-translational folding is crucial to ensure the production of biologically active proteins. The
ribosome can alter the folding pathways of nascent polypeptide chains, yet a structural …

COVID-19, resulting from infection by the SARS-CoV-2 virus, caused a contagious
pandemic. Even with the current vaccines, there is still an urgent need to develop effective …

Riboswitches are structured RNA elements that regulate gene expression upon binding to
small molecule ligands. Understanding the mechanisms by which small molecules impact …

Lowering the levels of the cellular prion protein (PrPC) is widely considered a promising
strategy for the treatment of prion diseases. Building on work that established immediate …

Prion diseases are a group of neurodegenerative disorders characterized by the
accumulation of misfolded prion protein (called PrPSc). Although conversion of the cellular …

Epitranscriptomic mRNA modifications affect gene expression, with their altered balance
detected in various cancers. YTHDF proteins contain the YTH reader domain recognizing …

Medicinal chemistry is facing new challenges in approaching precision medicine. Several
powerful new tools or improvements of already used tools are now available to medicinal …

Background Globally, COVID-19 has caused millions of deaths and led to unprecedented
socioeconomic damage. There is therefore, in addition to vaccination, an urgent need to …