APOE2: protective mechanism and therapeutic implications for Alzheimer's disease
Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
The vascular depression hypothesis: mechanisms linking vascular disease with depression
WD Taylor, HJ Aizenstein, GS Alexopoulos - Molecular psychiatry, 2013 - nature.com
Abstract The 'Vascular Depression'hypothesis posits that cerebrovascular disease may
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …
Development and aging of cortical thickness correspond to genetic organization patterns
There is a growing realization that early life influences have lasting impact on brain function
and structure. Recent research has demonstrated that genetic relationships in adults can be …
and structure. Recent research has demonstrated that genetic relationships in adults can be …
The forgotten APOE allele: a review of the evidence and suggested mechanisms for the protective effect of APOE ɛ2
Ongoing efforts to improve survival, and enhance quality of life have led biomedical
research to focus on disease and the mechanisms that increase risk for disease. The other …
research to focus on disease and the mechanisms that increase risk for disease. The other …
HYDRA: Revealing heterogeneity of imaging and genetic patterns through a multiple max-margin discriminative analysis framework
Multivariate pattern analysis techniques have been increasingly used over the past decade
to derive highly sensitive and specific biomarkers of diseases on an individual basis. The …
to derive highly sensitive and specific biomarkers of diseases on an individual basis. The …
[HTML][HTML] Predictors of ageing-related decline across multiple cognitive functions
It is critical to discover why some people's cognitive abilities age better than others'. We
applied multivariate growth curve models to data from a narrow-age cohort measured on a …
applied multivariate growth curve models to data from a narrow-age cohort measured on a …
Alzheimer's disease genetic risk factor APOE-ε4 also affects normal brain function
AM Di Battista, NM Heinsinger… - Current Alzheimer …, 2016 - ingentaconnect.com
APOE-4 is the strongest genetic risk factor for Alzheimer's disease (AD), and is associated
with an increase in the levels of amyloid deposition and an early age of onset. Recent data …
with an increase in the levels of amyloid deposition and an early age of onset. Recent data …
[HTML][HTML] APOE-related biomarker profiles in non-pathological aging and early phases of Alzheimer's disease
I Reinvang, T Espeseth, LT Westlye - Neuroscience & Biobehavioral …, 2013 - Elsevier
Individuals carrying the* E4 allele of the apolipoprotein E gene (APOE) are at increased risk
of developing Alzheimer's disease (AD). However, the biological mechanisms underlying …
of developing Alzheimer's disease (AD). However, the biological mechanisms underlying …
Machine learning based on Optical Coherence Tomography images as a diagnostic tool for Alzheimer's disease
X Wang, B Jiao, H Liu, Y Wang, X Hao… - CNS Neuroscience …, 2022 - Wiley Online Library
Aims We mainly evaluate retinal alterations in Alzheimer's disease (AD) patients, investigate
the associations between retinal changes with AD biomarkers, and explore an optimal …
the associations between retinal changes with AD biomarkers, and explore an optimal …