Over the last decade, studies have unraveled many aspects of endogenous production and
physiological functions of carbon monoxide (CO). The majority of endogenous CO is …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

Neuroglobin and cytoglobin are two recent additions to the family of heme-containing
respiratory proteins of man and other vertebrates. Here, we review the present state of …

Neuroglobin and cytoglobin reversibly bind oxygen in competition with the distal histidine,
and the observed oxygen affinity therefore depends on the properties of both ligands. In the …

Cytoglobin is a recently discovered vertebrate globin distantly related to myoglobin, and its
function is unknown. Here we present the first detailed analysis of the distribution and …

In 2000, the third member of the globin family was discovered in human and mouse brain
and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally similar to …

Cerebral hypoxia and ischemia trigger endogenous protective mechanisms that can prevent
or limit brain damage. Understanding these mechanisms may lead to new therapeutic …

Two new globin proteins have recently been discovered in vertebrates, neuroglobin in
neurons and cytoglobin in all tissues, both showing heme hexacoordination by the distal His …

Although reactive oxygen species (ROS) at physiological concentrations are required for
normal cell function, excessive production of ROS is detrimental to cells. Neuroglobin and …

New developments have forced a re-evaluation of our understanding of the structure and
function of hemoglobins. Leghemoglobins regulate oxygen affinity through a mechanism …