Current advances in digital cognitive assessment for preclinical Alzheimer's disease
There is a pressing need to capture and track subtle cognitive change at the preclinical
stage of Alzheimer's disease (AD) rapidly, cost‐effectively, and with high sensitivity …
stage of Alzheimer's disease (AD) rapidly, cost‐effectively, and with high sensitivity …
Alzheimer's disease: A review on the current trends of the effective diagnosis and therapeutics
AS Abdul Manap, R Almadodi, S Sultana… - Frontiers in Aging …, 2024 - frontiersin.org
The most prevalent cause of dementia is Alzheimer's disease. Cognitive decline and
accelerating memory loss characterize it. Alzheimer's disease advances sequentially …
accelerating memory loss characterize it. Alzheimer's disease advances sequentially …
Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70
A Keshavan, J Pannee, TK Karikari, JL Rodriguez… - Brain, 2021 - academic.oup.com
Alzheimer's disease has a preclinical stage when cerebral amyloid-β deposition occurs
before symptoms emerge, and when amyloid-β-targeted therapies may have maximum …
before symptoms emerge, and when amyloid-β-targeted therapies may have maximum …
Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight …
Background Midlife hypertension confers increased risk for cognitive impairment in late life.
The sensitive period for risk exposure and extent that risk is mediated through amyloid or …
The sensitive period for risk exposure and extent that risk is mediated through amyloid or …
Sex differences in episodic memory in early midlife: impact of reproductive aging
Objective: Few have characterized cognitive changes with age as a function of menopausal
stage relative to men, or sex differences in components of memory in early midlife. The study …
stage relative to men, or sex differences in components of memory in early midlife. The study …
Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real‐world population‐based cohort
PCL Ferreira, Y Zhang, B Snitz… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Plasma biomarkers—cost effective, non‐invasive indicators of Alzheimer's
disease (AD) and related disorders (ADRD)—have largely been studied in clinical research …
disease (AD) and related disorders (ADRD)—have largely been studied in clinical research …
Impact of sex and menopausal status on episodic memory circuitry in early midlife
Cognitive neuroscience of aging studies traditionally target participants age 65 and older.
However, epidemiological surveys show that many women report increased forgetfulness …
However, epidemiological surveys show that many women report increased forgetfulness …
Grip strength from midlife as an indicator of later-life brain health and cognition: evidence from a British birth cohort
Background Grip strength is an indicator of physical function with potential predictive value
for health in ageing populations. We assessed whether trends in grip strength from midlife …
for health in ageing populations. We assessed whether trends in grip strength from midlife …
Study protocol: Insight 46–a neuroscience sub-study of the MRC National Survey of Health and Development
Background Increasing age is the biggest risk factor for dementia, of which Alzheimer's
disease is the commonest cause. The pathological changes underpinning Alzheimer's …
disease is the commonest cause. The pathological changes underpinning Alzheimer's …
Cognition at age 70: life course predictors and associations with brain pathologies
Objective To investigate predictors of performance on a range of cognitive measures
including the Preclinical Alzheimer Cognitive Composite (PACC) and test for associations …
including the Preclinical Alzheimer Cognitive Composite (PACC) and test for associations …