[HTML][HTML] Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3′, 5′-monophosphate

J Castro, AM Harrington, PA Hughes, CM Martin, P Ge… - Gastroenterology, 2013 - Elsevier
Background & Aims Linaclotide is a minimally absorbed agonist of guanylate cyclase-C
(GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with …

Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities

T Wu, M Wang, W Wu, Q Luo, L Jiang, H Tao… - Journal of Venomous …, 2019 - SciELO Brasil
Spider venoms are known to contain proteins and polypeptides that perform various
functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and …

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

L Gong, F Gao, J Li, X Yu, X Ma, W Zheng, S Cui, K Liu… - Neuroscience, 2015 - Elsevier
Oxytocin (OT) plays an important role in pain modulation and antinociception in the central
nervous system. However, little is known about its peripheral effects. This study was …

Comparison of resveratrol supplementation and energy restriction effects on sympathetic nervous system activity and vascular reactivity: A randomized clinical trial

GHF Gonçalinho, A Roggerio, MFS Goes, SD Avakian… - Molecules, 2021 - mdpi.com
Background: Chronic sympathetic nervous system activation is associated with endothelial
dysfunction and cardiometabolic disease, which may be modulated by resveratrol (RSV) …

Regulation of nociceptive transduction and transmission by nitric oxide

A Bavencoffe, SR Chen, HL Pan - Vitamins & Hormones, 2014 - Elsevier
The potential involvement of nitric oxide (NO), a diffusible gaseous signaling messenger, in
nociceptive transduction and transmission has been extensively investigated. However …

Nitric oxide and potassium channels but not opioid and cannabinoid receptors mediate tramadol-induced peripheral antinociception in rat model of paw pressure …

RR Soares-Santos, DP Machado… - Canadian Journal of …, 2023 - cdnsciencepub.com
Tramadol, an analgesic classified as an “atypical opioid”, exhibits both opioid and non-
opioid mechanisms of action. This study aimed to explore these mechanisms, specifically …

Ang-(1–7) activates the NO/cGMP and ATP-sensitive K+ channels pathway to induce peripheral antinociception in rats

A Costa, G Galdino, T Romero, G Silva, S Cortes… - Nitric Oxide, 2014 - Elsevier
Abstract Angiotensin-(1–7) is a bioactive component of the renin–angiotensin system that is
formed endogenously and induces nitric oxide release in several tissues. The l …

Differential involvement of central and peripheral α2 adrenoreceptors in the antinociception induced by aerobic and resistance exercise

GG de Souza, ID Duarte… - Anesthesia & …, 2013 - journals.lww.com
BACKGROUND: Several studies have demonstrated antinociception induced by exercise;
however, the specific mechanisms for this effect are not well understood. Thus, we …

[HTML][HTML] The synthetic peptide PnPP-19 induces peripheral antinociception via activation of NO/cGMP/KATP pathway: Role of eNOS and nNOS

ACN Freitas, GC Silva, DF Pacheco, AMC Pimenta… - Nitric oxide, 2017 - Elsevier
Background and purpose: The peptide PnPP-19, derived from the spider toxin PnTx2-6
(renamed as δ-CNTX-Pn1c), potentiates erectile function by activating the nitrergic system …

Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation …

DL de Almeida, RCM Ferreira, FC Fonseca… - Nitric Oxide, 2024 - Elsevier
Background Cannabidiol (CBD) is the second most abundant pharmacologically active
component present in Cannabis sp. Unlike Δ-9-tetrahydrocannabinol (THC), it has no …