The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies
R Bai, Y Li, L Jian, Y Yang, L Zhao, M Wei - Molecular Cancer, 2022 - Springer
Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …
Insight in Hypoxia‐Mimetic Agents as Potential Tools for Mesenchymal Stem Cell Priming in Regenerative Medicine
A Nowak-Stępniowska, PN Osuchowska… - Stem Cells …, 2022 - Wiley Online Library
Hypoxia‐mimetic agents are new potential tools in MSC priming instead of hypoxia
incubators or chambers. Several pharmaceutical/chemical hypoxia‐mimetic agents can be …
incubators or chambers. Several pharmaceutical/chemical hypoxia‐mimetic agents can be …
Deciphering the mechanisms of HPV E6 mutations in the destabilization of E6/E6AP/p53 complex
In epithelial tumors, oncoprotein E6 binds with the ubiquitin ligase E6AP to form E6/E6AP
heterodimer; then this heterodimer recruits p53 to form E6/E6AP/p53 heterotrimer and …
heterodimer; then this heterodimer recruits p53 to form E6/E6AP/p53 heterotrimer and …
Inhibition or Deletion of Hydroxylases-Prolyl-4-Hydroxyases 3 Alleviates Lipopolysaccharide-induced Neuroinflammation and Neurobehavioral Deficiency
G Ou, X Jiang, Y Deng, J Dong, W Xu, X Zhang… - Neuroscience, 2022 - Elsevier
It is well known that neuroinflammation plays a key role in neurodegenerative diseases.
Hypoxia-inducible factor (HIF) and its hydroxylases-Prolyl-4-hydroxyases (PHDs) have been …
Hypoxia-inducible factor (HIF) and its hydroxylases-Prolyl-4-hydroxyases (PHDs) have been …
Факторы, индуцируемые гипоксией: детали создают «картину». Часть I. HIF-1
ГА Игнатенко, НН Бондаренко… - Фундаментальная и …, 2023 - fcm.kemsmu.ru
Аннотация В обзоре представлен сравнительный анализ научных данных о
структурно-функциональных особенностях субъединиц (HIF-1α и HIF-1β) …
структурно-функциональных особенностях субъединиц (HIF-1α и HIF-1β) …
[HTML][HTML] Hypoxia represses early responses of prostate and renal cancer cells to YM155 independent of HIF-1α and HIF-2α
D Danielpour, S Corum, SM Welford… - Current Research in …, 2022 - Elsevier
Abstract The imidazolium compound Sepantronium Bromide (YM155) successfully promotes
tumor regression in various pre-clinical models but has shown modest responses in human …
tumor regression in various pre-clinical models but has shown modest responses in human …
In Silico Analysis of Novel VHL Germline Mutations in Iranian RCH Patients
M Naseripour, K Bagherzadeh, G Khakpoor… - bioRxiv, 2022 - biorxiv.org
Abstract Von Hippel-Lindau (VHL) syndrome is an autosomal dominant inherited
multisystem neoplasia disorder caused by the VHL tumor suppressor gene, coding for VHL …
multisystem neoplasia disorder caused by the VHL tumor suppressor gene, coding for VHL …
Novel VHL Germline Mutations in Iranian RCH Patients
M Naseripour, K Bagherzadeh, GG Khakpoor… - 2023 - researchsquare.com
Abstract Von Hippel-Lindau (VHL) syndrome is an autosomal dominant inherited
multisystem neoplasia disorder caused by the VHL tumor suppressor gene, coding for VHL …
multisystem neoplasia disorder caused by the VHL tumor suppressor gene, coding for VHL …
Zhuyu Annao decoction promotes angiogenesis in mice with cerebral hemorrhage by inhibiting the activity of PHD3
L Wu, Y Hu, L Jiang, N Liang, P Liu… - Human & …, 2021 - journals.sagepub.com
Some traditional Chinese decoctions, such as Zhuyu Annao, exert favorable therapeutic
effects on acute cerebral hemorrhage, hemorrhagic stroke, and other neurological diseases …
effects on acute cerebral hemorrhage, hemorrhagic stroke, and other neurological diseases …