Target based chemotherapeutic advancement of ruthenium complexes

BK Kundu, S Mukhopadhyay - Coordination Chemistry Reviews, 2021 - Elsevier
Over the last few years, great emphasis has been given to develop ruthenium complexes to
act as target specified chemotherapeutic agents. Indeed, there are few reviews available …

Current understandings and clinical translation of nanomedicines for breast cancer therapy

Y Jiang, Z Jiang, M Wang, L Ma - Advanced drug delivery reviews, 2022 - Elsevier
Breast cancer is one of the most frequently diagnosed cancers that is threatening women's
life. Current clinical treatment regimens for breast cancer often involve neoadjuvant and …

Self‐Amplifying Iridium (III) Photosensitizer for Ferroptosis‐Mediated Immunotherapy Against Transferrin Receptor‐Overexpressing Cancer

YY Ling, WJ Wang, L Hao, XW Wu, JH Liang, H Zhang… - Small, 2022 - Wiley Online Library
Photoimmunotherapy is attractive for cancer treatment due to its spatial controllability and
sustained responses. This work presents a ferrocene‐containing Ir (III) photosensitizer …

An overview on the anticancer activity of Ru (II)/acylthiourea complexes

GH Ribeiro, AR Costa, AR de Souza… - Coordination Chemistry …, 2023 - Elsevier
This review outlines research on the development of ruthenium complexes containing
acylthiourea ligands with potential antitumor activity, which have been leveraged in recent …

Ruthenium-based antitumor drugs and delivery systems from monotherapy to combination therapy

Y Lu, D Zhu, Q Le, Y Wang, W Wang - Nanoscale, 2022 - pubs.rsc.org
Ruthenium complex is an important compound group for antitumor drug research and
development. NAMI-A, KP1019, TLD1433 and other ruthenium complexes have entered …

Exploring the potential of metallodrugs as chemotherapeutics for triple negative breast cancer

N Nayeem, M Contel - Chemistry–A European Journal, 2021 - Wiley Online Library
This review focuses on studies of coordination and organometallic compounds as potential
chemotherapeutics against triple negative breast cancer (TNBC) which has one of the …

Rationally designed ruthenium complexes for breast cancer therapy

G Golbaghi, A Castonguay - Molecules, 2020 - mdpi.com
Since the discovery of the anticancer potential of ruthenium-based complexes, several
species were reported as promising candidates for the treatment of breast cancer, which …

New iron metabolic pathways and chelation targeting strategies affecting the treatment of all types and stages of cancer

GJ Kontoghiorghes - International Journal of Molecular Sciences, 2022 - mdpi.com
There is new and increasing evidence from in vitro, in vivo and clinical studies implicating
the pivotal role of iron and associated metabolic pathways in the initiation, progression and …

DNA damage and antioxidant properties of CORM-2 in normal and cancer cells

M Juszczak, M Kluska, D Wysokiński, K Woźniak - Scientific Reports, 2020 - nature.com
In this study, we compared the effect of tricarbonyldichlororuthenium (II) dimer (CORM-2)
and its CO-depleted molecule (iCORM-2) on human peripheral blood mononuclear cells …

Recent progress in small molecule agents for the targeted therapy of triple-negative breast cancer

R Islam, KW Lam - European Journal of Medicinal Chemistry, 2020 - Elsevier
Triple-negative breast cancer (TNBC) is the most aggressive type of cancer, with a high risk
of death on recurrence. To date, there is a lack of approved targeted agents for the treatment …