[HTML][HTML] Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS

D Nehar-Belaid, M Sokolowski, S Ravichandran… - Seminars in …, 2023 - Elsevier
Vaccines are among the greatest inventions in medicine, leading to the elimination or
control of numerous diseases, including smallpox, polio, measles, rubella, and, most …

IL‐21‐IgFc immunotherapy alters transcriptional landscape of lymph node cells leading to enhanced flu vaccine response in aging and SIV infection

S Pallikkuth, D Kvistad, T Sirupangi, A Kizhner… - Aging cell, 2023 - Wiley Online Library
Aging people living with HIV (PWH) frequently manifest impaired antibody (Ab) responses to
seasonal flu vaccination which has been attributed to ongoing inflammation and immune …

A supervised Bayesian factor model for the identification of multi-omics signatures

JP Gygi, A Konstorum, S Pawar, E Aron… - …, 2024 - academic.oup.com
Motivation Predictive biological signatures provide utility as biomarkers for disease
diagnosis and prognosis, as well as prediction of responses to vaccination or therapy. These …

Reduced Serological Response to COVID-19 Booster Vaccine is Associated with Reduced B Cell Memory in Patients With Inflammatory Bowel Disease; VARIATION …

J Doherty, N O'Morain, R Stack… - Journal of Crohn's …, 2023 - academic.oup.com
Abstract Background and Aims Patients with inflammatory bowel disease [IBD] have an
attenuated response to initial COVID-19 vaccination. We sought to characterize the impact of …

[PDF][PDF] Genetic demultiplexing across data modalities in single-cell and single-nuclei experiments using the CellDemux framework

M Zoodsma, Q Zhan, S Kumar, J Botey-Bataller… - Systems biology to …, 2024 - d-nb.info
Multiplexed single-cell experiment designs are superior in terms of reduced batch effects,
increased cost-effectiveness, throughput and statistical power. However, current …

From bench to bedside: Practical considerations for translational studies using single-cell mass cytometry

IA Stelzer, D Feyaerts, EA Ganio, JN Amar… - … Biology with Single …, 2024 - Elsevier
Mass cytometry is a high-plex single-cell proteomics technique that allows biomedical
researchers to interrogate proteins expressed on and within cells on a per-cell basis to …