Impact of miRNA in atherosclerosis

Y Lu, T Thavarajah, W Gu, J Cai… - … , thrombosis, and vascular …, 2018 - Am Heart Assoc
e160 Arterioscler Thromb Vasc Biol September 2018 were actively exported to the
cytoplasm with exportin-5 in a Ran-GTP–dependent manner. In the cytoplasm, the transition …

Role of resident stem cells in vessel formation and arteriosclerosis

L Zhang, S Issa Bhaloo, T Chen, B Zhou… - Circulation research, 2018 - Am Heart Assoc
Vascular, resident stem cells are present in all 3 layers of the vessel wall; they play a role in
vascular formation under physiological conditions and in remodeling in pathological …

Peptide vaccine against ADAMTS-7 ameliorates atherosclerosis and postinjury neointima hyperplasia

Z Ma, C Mao, X Chen, S Yang, Z Qiu, B Yu, Y Jia… - Circulation, 2023 - Am Heart Assoc
Background: The metalloprotease ADAMTS-7 (a disintegrin and metalloproteinase with
thrombospondin type 1 motif 7) is a novel locus associated with human coronary …

Single-cell RNA-sequencing and metabolomics analyses reveal the contribution of perivascular adipose tissue stem cells to vascular remodeling

W Gu, WN Nowak, Y Xie, A Le Bras, Y Hu… - … , and vascular biology, 2019 - Am Heart Assoc
Objective: Perivascular adipose tissue (PVAT) plays a vital role in maintaining vascular
homeostasis. However, most studies ascribed the function of PVAT in vascular remodeling …

Adventitial cell atlas of wt (wild type) and ApoE (apolipoprotein E)-deficient mice defined by single-cell RNA sequencing

W Gu, Z Ni, YQ Tan, J Deng, SJ Zhang… - … , and vascular biology, 2019 - Am Heart Assoc
Objective—Vascular adventitia encompasses progenitors and is getting recognized as the
major site of inflammation in early stage of atherosclerosis. However, the cellular atlas of the …

Leptin-induced signaling pathways in cancer cell migration and invasion

A Ghasemi, J Saeidi, M Azimi-Nejad, SI Hashemy - Cellular Oncology, 2019 - Springer
Background Increasing evidence indicates that obesity is associated with tumor
development and progression. Leptin is an adipocyte-related hormone with a key role in …

Nonbone Marrow CD34+ Cells Are Crucial for Endothelial Repair of Injured Artery

L Jiang, T Chen, S Sun, R Wang, J Deng, L Lyu… - Circulation …, 2021 - Am Heart Assoc
Rationale: Endothelial cells play a critical role in multiple cardiovascular diseases.
Circulating CD34+ cells are believed to be endothelial progenitors that have been used to …

Vascular development

MW Majesky - Arteriosclerosis, thrombosis, and vascular biology, 2018 - Am Heart Assoc
The vascular system forms as a branching network of endothelial cells that acquire identity
as arterial, venous, hemogenic, or lymphatic. Endothelial specification depends on gene …

Ion channels and vascular diseases

J Cheng, J Wen, N Wang, C Wang, Q Xu… - … , and vascular biology, 2019 - Am Heart Assoc
Transient receptor potential (TRP) channels are not only the major contributors to Ca2+
signaling but also the targets of Ca2+ signaling. Ca2+ regulation of TRP channels involves 3 …

Vascular stem/progenitor cells in vessel injury and repair

J Tao, X Cao, B Yu, A Qu - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Vascular repair upon vessel injury is essential for the maintenance of arterial homeostasis
and function. Stem/progenitor cells were demonstrated to play a crucial role in regeneration …