Respiratory syncytial virus entry and how to block it

MB Battles, JS McLellan - Nature Reviews Microbiology, 2019 - nature.com
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in
young children and elderly people. Although the virus was isolated in 1955, an effective …

Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology

JS Tregoning, J Schwarze - Clinical microbiology reviews, 2010 - Am Soc Microbiol
In global terms, respiratory viral infection is a major cause of morbidity and mortality. Infancy,
in particular, is a time of increased disease susceptibility and severity. Early-life viral …

Respiratory syncytial virus: virology, reverse genetics, and pathogenesis of disease

PL Collins, R Fearns, BS Graham - Challenges and opportunities for …, 2013 - Springer
Human respiratory syncytial virus (RSV) is an enveloped, nonsegmented negative-strand
RNA virus of family Paramyxoviridae. RSV is the most complex member of the family in …

Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years

PL Collins, JA Melero - Virus research, 2011 - Elsevier
Human respiratory syncytial virus (RSV) is a ubiquitous pathogen that infects everyone
worldwide early in life and is a leading cause of severe lower respiratory tract disease in the …

Viral and host factors in human respiratory syncytial virus pathogenesis

PL Collins, BS Graham - Journal of virology, 2008 - Am Soc Microbiol
Human respiratory syncytial virus (RSV) was first isolated in 1956 from a laboratory
chimpanzee with upper respiratory tract disease (for general reviews, see references 21, 57 …

Immunity to RSV in early-life

L Lambert, AM Sagfors, PJM Openshaw… - Frontiers in …, 2014 - frontiersin.org
Respiratory Syncytial Virus (RSV) is the commonest cause of severe respiratory infection in
infants, leading to over 3 million hospitalizations and around 66,000 deaths worldwide each …

Respiratory syncytial virus infection promotes necroptosis and HMGB1 release by airway epithelial cells

J Simpson, Z Loh, MA Ullah, JP Lynch… - American journal of …, 2020 - atsjournals.org
Rationale: Respiratory syncytial virus (RSV) bronchiolitis causes significant infant mortality.
Bronchiolitis is characterized by airway epithelial cell (AEC) death; however, the mode of …

Immunological lessons from respiratory syncytial virus vaccine development

TJ Ruckwardt, KM Morabito, BS Graham - Immunity, 2019 - cell.com
Respiratory syncytial virus (RSV) has eluded active vaccination efforts for more than five
decades and continues to cause substantial morbidity and mortality in infants, the …

Role of type I interferon (IFN) in the respiratory syncytial virus (RSV) immune response and disease severity

DR Hijano, LD Vu, LM Kauvar, RA Tripp… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract
disease in children< 2 years of age. Increased morbidity and mortality have been reported in …

Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I

Z Ling, KC Tran, MN Teng - Journal of virology, 2009 - Am Soc Microbiol
ABSTRACT A wide variety of RNA viruses have been shown to produce proteins that inhibit
interferon (IFN) production and signaling. For human respiratory syncytial virus (RSV), the …