Automated immunoassays used to evaluate thyroid function are vulnerable to different types
of interference that can affect clinical decisions. This review provides a detailed overview of …

Circadian rhythmicity is an approximately 24-h cell-autonomous period driven by
transcription–translation feedback loops of specific genes, which are referred to as 'circadian …

Immunoassays are powerful qualitative and quantitative analytical techniques. Since the first
description of an immunoassay method in 1959, advances have been made in assay …

Background: Despite being the most performed laboratory endocrine investigation, the
optimum use of thyroid tests (thyrotropin [TSH] and thyroid hormone [TH] measurement) is …

Objective To explore whether thyroid stimulating hormone (TSH) concentration in patients
with a diagnosis of hypothyroidism is associated with increased all cause mortality and a …

This paper provides the reader with an overview of our current knowledge of hypothalamic‐
pituitary‐thyroid feedback from a cybernetic standpoint. Over the past decades we have …

Transient congenital hypothyroidism (TCH) refers to congenital hypothyroidism which
spontaneously resolves in the first few months or years of life. Currently, there is a paucity of …

Serum thyrotropin (TSH) is considered the single most sensitive and specific measure of
thyroid function in the general population owing to its negative logarithmic association with …

Objective TSH is a sensitive indicator of thyroid function. In subclinical hypothyroidism,
however, serum TSH concentrations are elevated despite normal thyroid hormone levels …

Abstract Design Macro TSH is a large molecular-sized TSH that is mostly a complex of TSH
and IgG. Patients with macro TSH have elevated serum TSH and normal free thyroxine …