BACKGROUND: The most frequent clinical condition exemplifying the interplay between
iron and immune function is the anemia of chronic disease (ACD). METHODS: Based on a …

Iron can accumulate in the liver in a variety of conditions, including congenital, systemic iron-
loading conditions (hereditary hemochromatosis), conditions associated with systemic …

Iron homeostasis plays a critical role in many physiological processes, notably synthesis of
heme proteins. Dietary iron sensing and inflammation converge in the control of iron …

Genetic hemochromatosis (GH) is an iron overload disorder mainly due to the C282Y
mutation of the HFE gene. The possibility of bone involvement was only recently recognized …

Iron overload diseases of genetic origin are an ever changing world, due to major advances
in genetics and molecular biology. Five major categories are now established: HFE-related …

Hereditary hemochromatosis (HH) is an autosomal recessive disorder characterized by
enhanced intestinal absorption of dietary iron. Without therapeutic intervention, iron …

205 (4), 297-318── Iron is fastidiously utilized by living cells, since it is an essential
element, but is toxic in excess. Cells take up iron via a transferrin-transferrin receptor …

The term hemochromatosis encompasses at least four types of genetic iron overload
conditions, most of them recently distinguished from one another as a result of the …

The number of new genes implicated in iron metabolism has dramatically increased during
the last few years. Alterations of these genes may cause hyperferritinemia associated or not …

Hemochromatosis is a genetically heterogeneous condition. Mutations in the recently
described hemojuvelin gene were found in patients with juvenile hemochromatosis, who …