3D printing: an emerging tool for novel microfluidics and lab-on-a-chip applications

AA Yazdi, A Popma, W Wong, T Nguyen, Y Pan… - Microfluidics and …, 2016 - Springer
In the past few years, 3D printing technology has witnessed an explosive growth,
penetrating various aspects of our lives. Current best-in-class 3D printers can fabricate …

EMT-associated heterogeneity in circulating tumor cells: sticky friends on the road to metastasis

A Genna, AM Vanwynsberghe, AV Villard, C Pottier… - Cancers, 2020 - mdpi.com
Epithelial–mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced
ability to adapt to diverse microenvironments encountered during the metastatic spread …

Aspiration-assisted bioprinting for precise positioning of biologics

B Ayan, DN Heo, Z Zhang, M Dey, A Povilianskas… - Science …, 2020 - science.org
Three-dimensional (3D) bioprinting is an appealing approach for building tissues; however,
bioprinting of mini-tissue blocks (ie, spheroids) with precise control on their positioning in 3D …

Clusters of circulating tumor cells traverse capillary-sized vessels

SH Au, BD Storey, JC Moore, Q Tang… - Proceedings of the …, 2016 - National Acad Sciences
Multicellular aggregates of circulating tumor cells (CTC clusters) are potent initiators of
distant organ metastasis. However, it is currently assumed that CTC clusters are too large to …

Pulsatile flow in microfluidic systems

B Dincau, E Dressaire, A Sauret - Small, 2020 - Wiley Online Library
This review describes the current knowledge and applications of pulsatile flow in microfluidic
systems. Elements of fluid dynamics at low Reynolds number are first described in the …

3D-printed biosensor arrays for medical diagnostics

M Sharafeldin, A Jones, JF Rusling - Micromachines, 2018 - mdpi.com
While the technology is relatively new, low-cost 3D printing has impacted many aspects of
human life. 3D printers are being used as manufacturing tools for a wide variety of devices in …

CFD analysis of microfluidic droplet formation in non–Newtonian liquid

SG Sontti, A Atta - Chemical Engineering Journal, 2017 - Elsevier
A three-dimensional, volume-of-fluid (VOF) based CFD model is presented to investigate
droplet formation in a microfluidic T-junction. Genesis of Newtonian droplets in non …

Microfluidics for studying metastatic patterns of lung cancer

M Ruzycka, MR Cimpan, I Rios-Mondragon… - Journal of …, 2019 - Springer
The incidence of lung cancer continues to rise worldwide. Because the aggressive
metastasis of lung cancer cells is the major drawback of successful therapies, the crucial …

Image-based spatio-temporal model of drug delivery in a heterogeneous vasculature of a solid tumor—Computational approach

FM Kashkooli, M Soltani, M Rezaeian… - Microvascular …, 2019 - Elsevier
The solute transport distribution in a tumor is an important criterion in the evaluation of the
cancer treatment efficacy. The fraction of killed cells after each treatment can quantify the …

A new compressive scheme to simulate species transfer across fluid interfaces using the volume-of-fluid method

J Maes, C Soulaine - Chemical Engineering Science, 2018 - Elsevier
We present a new compressive scheme to simulate species transfer across fluid interfaces
using the Volume-Of-Fluid method. We show that at high Péclet numbers, the standard …