Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Immunity and inflammation in atherosclerosis

D Wolf, K Ley - Circulation research, 2019 - Am Heart Assoc
There is now overwhelming experimental and clinical evidence that atherosclerosis is a
chronic inflammatory disease. Lessons from genome-wide association studies, advanced in …

T cell subsets and functions in atherosclerosis

R Saigusa, H Winkels, K Ley - Nature Reviews Cardiology, 2020 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …

Meta-analysis of leukocyte diversity in atherosclerotic mouse aortas

A Zernecke, H Winkels, C Cochain… - Circulation …, 2020 - Am Heart Assoc
The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …

Inflammation, Immunity, and Infection in Atherothrombosis: JACC Review Topic of the Week

P Libby, J Loscalzo, PM Ridker, ME Farkouh… - Journal of the American …, 2018 - jacc.org
Observations on human and experimental atherosclerosis, biomarker studies, and now a
large-scale clinical trial support the operation of immune and inflammatory pathways in this …

The immunology of atherosclerosis

A Gisterå, GK Hansson - Nature reviews nephrology, 2017 - nature.com
Cardiovascular disease is the leading cause of death worldwide, both in the general
population and among patients with chronic kidney disease (CKD). In most cases, the …

The integration of inflammaging in age-related diseases

T Fulop, JM Witkowski, F Olivieri, A Larbi - Seminars in immunology, 2018 - Elsevier
Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …

New insights into the role of inflammation in the pathogenesis of atherosclerosis

MY Wu, CJ Li, MF Hou, PY Chu - International journal of molecular …, 2017 - mdpi.com
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of
lipids, smooth muscle cell proliferation, cell apoptosis, necrosis, fibrosis, and local …

Inflammation and plaque vulnerability

GK Hansson, P Libby, I Tabas - Journal of internal medicine, 2015 - Wiley Online Library
Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs at
sites of blood flow disturbance. The disease usually remains silent until a breakdown of …

[HTML][HTML] Inflammation in atherosclerosis

S Taleb - Archives of cardiovascular diseases, 2016 - Elsevier
Atherosclerosis is an inflammatory disease within the arterial wall that is responsible for
several important adverse vascular events, including coronary artery disease, myocardial …