Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

[Frontiers in Bioscience 14, 5291-5338, June 1, 2009] 5291 Neurobiology of depression,
fibromyalgia and neuropathic pain Vladimi Page 1 [Frontiers in Bioscience 14, 5291-5338, June …

Unsatisfactory clinical efficacy and a variety of adverse effects of current antidepressant
drugs have incited search for better therapy. Zinc, an antagonist of the glutamate/N-methyl-D …

Drugs acting at metabotropic glutamate receptors (mGluRs) are among the most promising
agents under development for the treatment of psychiatric disorders. The research in this …

In the present study, we examined the anxiolytic and antidepressant effects of the mixture of
alpha-and beta-amyrin (AMY), pentacyclic triterpenes isolated from the stem bark resin of …

It was well established that compounds which decrease glutamatergic transmission via
blockade of NMDA or group I mGlu receptors produce anxiolytic-and antidepressant-like …

This study tested the potential antidepressant activity of minocycline alone or combined with
two traditional antidepressant drugs or several glutamate receptor antagonists, using the …

Recent studies have strengthened the role of the abnormalities in neurotrophic pathways in
the pathophysiology of depression. It has been shown that the depletion of growth factors …

Tramadol (TR) is a synthetic analgesic drug with central function that can induce seizures
even at therapeutic doses. The exact mechanism of TR effect on seizure generation is not …

Metabotropic glutamate receptors (mGluRs) have been proposed as novel targets for the
treatment of a variety of disorders. Recently, highly selective allosteric modulators of the …