[HTML][HTML] A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming
The methods for the culture and cardiomyocyte differentiation of human embryonic stem
cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex …
cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex …
Induced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility
A Adegunsoye, NM Gonzales… - Annual Review of …, 2023 - annualreviews.org
Many human phenotypes are impossible to recapitulate in model organisms or immortalized
human cell lines. Induced pluripotent stem cells (iPSCs) offer a way to study disease …
human cell lines. Induced pluripotent stem cells (iPSCs) offer a way to study disease …
Human engineered heart tissue models for disease modeling and drug discovery
The emergence of human induced pluripotent stem cells (hiPSCs) and efficient
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
Cardiomyocyte Na+ and Ca2+ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors
Abstract Cardiomyocyte Na+ and Ca 2+ mishandling, upregulated Ca 2+/calmodulin-
dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are …
dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are …
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy
Aims Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite
significant progress in understanding the genetic aetiologies of DCM, the molecular …
significant progress in understanding the genetic aetiologies of DCM, the molecular …
Utility of iPSC-derived cells for disease modeling, drug development, and cell therapy
MW Nicholson, CY Ting, DZH Chan, YC Cheng… - Cells, 2022 - mdpi.com
The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the
molecular mechanisms of human disease, drug discovery, and regenerative medicine. As …
molecular mechanisms of human disease, drug discovery, and regenerative medicine. As …
[HTML][HTML] A deep learning platform to assess drug proarrhythmia risk
R Serrano, DAM Feyen, AAN Bruyneel, AP Hnatiuk… - Cell Stem Cell, 2023 - cell.com
Drug safety initiatives have endorsed human iPSC-derived cardiomyocytes (hiPSC-CMs) as
an in vitro model for predicting drug-induced cardiac arrhythmia. However, the extent to …
an in vitro model for predicting drug-induced cardiac arrhythmia. However, the extent to …
Generating 3D human cardiac constructs from pluripotent stem cells
C Liu, X Feng, G Li, P Gokulnath, J Xiao - EBioMedicine, 2022 - thelancet.com
Human pluripotent stem cell (hPSC) technology has offered nearly infinite opportunities to
model all kinds of human diseases in vitro. Cardiomyocytes derived from hPSCs have …
model all kinds of human diseases in vitro. Cardiomyocytes derived from hPSCs have …
Human iPSC modeling of heart disease for drug development
Human induced pluripotent stem cells (hiPSCs) have emerged as a promising platform for
pharmacogenomics and drug development. In cardiology, they make it possible to produce …
pharmacogenomics and drug development. In cardiology, they make it possible to produce …
The suitability of high throughput automated patch clamp for physiological applications
A Obergrussberger, I Rinke‐Weiß… - The Journal of …, 2022 - Wiley Online Library
Although automated patch clamp (APC) devices have been around for many years and have
become an integral part of many aspects of drug discovery, high throughput instruments with …
become an integral part of many aspects of drug discovery, high throughput instruments with …