Therapeutic implications of the metabolic changes associated with BRAF inhibition in melanoma
AW Loftus, M Zarei, H Kakish, O Hajihassani… - Cancer treatment …, 2024 - Elsevier
Melanoma metabolism can be reprogrammed by activating BRAF mutations. These
mutations are present in up to 50% of cutaneous melanomas, with the most common being …
mutations are present in up to 50% of cutaneous melanomas, with the most common being …
Role of mitochondria and potential of mitochondria-targeted therapy in BRAF mutant cancer: A review
Y Gao, H Zheng - Critical Reviews in Oncology/Hematology, 2024 - Elsevier
The classical mitogen-activated protein kinase (MAPK) signaling pathway, the Ras/Raf/MEK
(mitogen-activated protein kinase/ERK kinase)/ERK protein kinase cascade, is a conserved …
(mitogen-activated protein kinase/ERK kinase)/ERK protein kinase cascade, is a conserved …
Secreted Apoe rewires melanoma cell state vulnerability to ferroptosis
S More, J Bonnereau, D Wouters, X Spotbeen… - Science …, 2024 - science.org
A major therapeutic barrier in melanoma is the coexistence of diverse cellular states marked
by distinct metabolic traits. Transitioning from a proliferative to an invasive melanoma …
by distinct metabolic traits. Transitioning from a proliferative to an invasive melanoma …
Role of Rho/MRTF in Aggressive Vemurafenib-Resistant Murine Melanomas and Immune Checkpoint Upregulation
BM Foda, RR Neubig - International Journal of Molecular Sciences, 2023 - mdpi.com
Cutaneous melanoma is the deadliest skin cancer. Most have Ras-MAPK pathway
(BRAFV600E or NRAS) mutations and highly effective targeted therapies exist; however …
(BRAFV600E or NRAS) mutations and highly effective targeted therapies exist; however …
Stochastic fluctuations drive non-genetic evolution of proliferation in clonal cancer cell populations
C Ortega-Sabater, G F. Calvo, J Dinić… - Bulletin of Mathematical …, 2023 - Springer
Evolutionary dynamics allows us to understand many changes happening in a broad variety
of biological systems, ranging from individuals to complete ecosystems. It is also behind a …
of biological systems, ranging from individuals to complete ecosystems. It is also behind a …
Metabolism-dependent secondary effect of anti-MAPK cancer therapy on DNA repair
F Aubé, N Fontrodona, L Guiguettaz, E Vallin… - NAR …, 2024 - academic.oup.com
Amino acid bioavailability impacts mRNA translation in a codon-dependent manner. Here,
we report that the anti-cancer MAPK inhibitors (MAPKi) decrease the intracellular …
we report that the anti-cancer MAPK inhibitors (MAPKi) decrease the intracellular …