To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

Vertical migration is a geographically and taxonomically widespread behaviour among
zooplankton that spans across diel and seasonal timescales. The shorter‐term diel vertical …

The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by
the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent …

Life is a cyclical chemical process that is regulated in four dimensions. We distinguish parts
of the cycle: development describes the changes from single cell to adult, and aging the …

The treatment of cultured rat-1 fibroblasts or H35 hepatoma cells with high concentrations of
serum induces the circadian expression of various genes whose transcription also oscillates …

Here we describe the cloning and characterization of a PAS domain transcription factor
termed endothelial PAS-1 (EPAS1). This protein shares 48% sequence identity with hypoxia …

Basic helix–loop–helix (bHLH) transcription factors (TFs) belong to a family of transcriptional
regulators present in three eukaryotic kingdoms. Many different functions have been …

▪ Abstract A growing number of cellular regulatory mechanisms are being linked to protein
modification by the polypeptide ubiquitin. These include key transitions in the cell cycle …

Light is a major environmental signal for circadian rhythms. We have identified and analyzed
cry, a novel Drosophila cryptochrome gene. All characterized family members are directly …