From patterns to patients: Advances in clinical machine learning for cancer diagnosis, prognosis, and treatment

K Swanson, E Wu, A Zhang, AA Alizadeh, J Zou - Cell, 2023 - cell.com
Machine learning (ML) is increasingly used in clinical oncology to diagnose cancers, predict
patient outcomes, and inform treatment planning. Here, we review recent applications of ML …

Toward explainable artificial intelligence for precision pathology

F Klauschen, J Dippel, P Keyl… - Annual Review of …, 2024 - annualreviews.org
The rapid development of precision medicine in recent years has started to challenge
diagnostic pathology with respect to its ability to analyze histological images and …

Machine learning for genetics-based classification and treatment response prediction in cancer of unknown primary

I Moon, J LoPiccolo, SC Baca, LM Sholl, KL Kehl… - Nature Medicine, 2023 - nature.com
Cancer of unknown primary (CUP) is a type of cancer that cannot be traced back to its
primary site and accounts for 3–5% of all cancers. Established targeted therapies are …

Pan-cancer whole-genome comparison of primary and metastatic solid tumours

F Martínez-Jiménez, A Movasati, SR Brunner… - Nature, 2023 - nature.com
Metastatic cancer remains an almost inevitably lethal disease,–. A better understanding of
disease progression and response to therapies therefore remains of utmost importance …

A review and comparative study of cancer detection using machine learning: SBERT and SimCSE application

M Mokoatle, V Marivate, D Mapiye, R Bornman… - BMC …, 2023 - Springer
Background Using visual, biological, and electronic health records data as the sole input
source, pretrained convolutional neural networks and conventional machine learning …

Artificial intelligence-based risk stratification, accurate diagnosis and treatment prediction in gynecologic oncology

Y Jiang, C Wang, S Zhou - Seminars in cancer biology, 2023 - Elsevier
As data-driven science, artificial intelligence (AI) has paved a promising path toward an
evolving health system teeming with thrilling opportunities for precision oncology …

Feasibility of whole‐genome sequencing‐based tumor diagnostics in routine pathology practice

KG Samsom, LJ Schipper, P Roepman… - The Journal of …, 2022 - Wiley Online Library
The current increase in number and diversity of targeted anticancer agents poses
challenges to the logistics and timeliness of molecular diagnostics (MolDx), resulting in …

Integrative modeling of tumor genomes and epigenomes for enhanced cancer diagnosis by cell-free DNA

M Bae, G Kim, TR Lee, JM Ahn, H Park, SR Park… - Nature …, 2023 - nature.com
Multi-cancer early detection remains a key challenge in cell-free DNA (cfDNA)-based liquid
biopsy. Here, we perform cfDNA whole-genome sequencing to generate two test datasets …

[HTML][HTML] Advances in machine learning for tumour classification in cancer of unknown primary: A mini-review

K Oróstica, F Mardones, YA Bernal, S Molina… - Cancer Letters, 2024 - Elsevier
Cancers of unknown primary (CUP) are a heterogeneous group of aggressive metastatic
cancers where standardised diagnostic techniques fail to identify the organ where it …

Deep-learning model for tumor-type prediction using targeted clinical genomic sequencing data

M Darmofal, S Suman, G Atwal, M Toomey, JF Chen… - Cancer discovery, 2024 - AACR
Tumor type guides clinical treatment decisions in cancer, but histology-based diagnosis
remains challenging. Genomic alterations are highly diagnostic of tumor type, and tumor …