MicroRNA dysregulations in Merkel cell carcinoma: Molecular mechanisms and clinical applications

C Mazziotta, CF Cervellera, C Lanzillotti… - Journal of Medical …, 2023 - Wiley Online Library
Merkel cell carcinoma (MCC) is an aggressive skin malignancy with two distinct etiologies.
The first, which accounts for the highest proportion, is caused by Merkel cell polyomavirus …

Harnessing epigenetics for breast cancer therapy: The role of DNA methylation, histone modifications, and MicroRNA

J Szczepanek, M Skorupa, J Jarkiewicz-Tretyn… - International Journal of …, 2023 - mdpi.com
Breast cancer exhibits various epigenetic abnormalities that regulate gene expression and
contribute to tumor characteristics. Epigenetic alterations play a significant role in cancer …

miRNAs: The road from bench to bedside

G Iacomino - Genes, 2023 - mdpi.com
miRNAs are small noncoding RNAs that control gene expression at the posttranscriptional
level. It has been recognised that miRNA dysregulation reflects the state and function of cells …

MicroRNAs in cancer and cardiovascular disease

M Ilieva, R Panella, S Uchida - Cells, 2022 - mdpi.com
Although cardiac tumor formation is rare, accumulating evidence suggests that the two
leading causes of deaths, cancers, and cardiovascular diseases are similar in terms of …

Pharmacogenetics of drug metabolism: the role of gene polymorphism in the regulation of doxorubicin safety and efficacy

AA Bagdasaryan, VN Chubarev, EA Smolyarchuk… - Cancers, 2022 - mdpi.com
Simple Summary The effectiveness and safety of the anti-cancer agent doxorubicin
(anthracycline group medicine) depend on the metabolism and retention of the drug in the …

Autophagy in BRAF-mutant cutaneous melanoma: recent advances and therapeutic perspective

E Fratta, G Giurato, R Guerrieri, F Colizzi… - Cell Death …, 2023 - nature.com
Macroautophagy, hereafter referred to as autophagy, represents a highly conserved
catabolic process that maintains cellular homeostasis. At present, the role of autophagy in …

Nucleic acid-based artificial nanocarriers for gene therapy

L Zhu, J Luo, K Ren - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Nucleic acid nanotechnology is a powerful tool in the fields of biosensing and nanomedicine
owing to their high editability and easy synthesis and modification. Artificial nucleic acid …

[HTML][HTML] Screening of miRNAs as prognostic biomarkers and their associated hub targets across Hepatocellular carcinoma using survival-based bioinformatics …

P Singh, R Solanki, A Tasneem, S Suri, H Kaur… - Journal of Genetic …, 2024 - Elsevier
Background The hepatocellular carcinoma (HCC) incident rate is gradually increasing
yearly despite all the research and efforts taken by scientific communities and governing …

The role of MicroRNAs in breast cancer and the challenges of their clinical application

JP Muñoz, P Pérez-Moreno, Y Pérez, GM Calaf - Diagnostics, 2023 - mdpi.com
MicroRNAs (miRNAs) constitute a subclass of non-coding RNAs that exert substantial
influence on gene-expression regulation. Their tightly controlled expression plays a pivotal …

[HTML][HTML] Current clinical trials with non-coding RNA-based therapeutics in malignant diseases: a systematic review

M Ito, Y Miyata, M Okada - Translational Oncology, 2023 - Elsevier
This systematic review aimed to shed light on the trend of current clinical trials of non-coding
RNA (ncRNA)-based therapeutics for malignant diseases. We conducted a database search …