Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease
The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …
Dopamine and glutamate regulate striatal acetylcholine in decision-making
Striatal dopamine and acetylcholine are essential for the selection and reinforcement of
motor actions and decision-making. In vitro studies have revealed an intrastriatal circuit in …
motor actions and decision-making. In vitro studies have revealed an intrastriatal circuit in …
[HTML][HTML] Cell type specificity for circuit output in the midbrain dopaminergic system
S Blaess, S Krabbe - Current opinion in neurobiology, 2023 - Elsevier
Midbrain dopaminergic neurons are a relatively small group of neurons in the mammalian
brain controlling a wide range of behaviors. In recent years, increasingly sophisticated …
brain controlling a wide range of behaviors. In recent years, increasingly sophisticated …
Large language models streamline automated machine learning for clinical studies
A knowledge gap persists between machine learning (ML) developers (eg, data scientists)
and practitioners (eg, clinicians), hampering the full utilization of ML for clinical data …
and practitioners (eg, clinicians), hampering the full utilization of ML for clinical data …
Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson's disease model
NLG Del Rey, N Hernández-Pinedo, M Carrillo… - npj Parkinson's …, 2024 - nature.com
The differential vulnerability of dopaminergic neurons of the substantia nigra pars compacta
(SNc) is a critical and unresolved question in Parkinson´ s disease. Studies in mice show …
(SNc) is a critical and unresolved question in Parkinson´ s disease. Studies in mice show …
Dopamine pathways mediating affective state transitions after sleep loss
The pathophysiology of affective disorders—particularly circuit-level mechanisms underlying
bidirectional, periodic affective state transitions—remains poorly understood. In patients …
bidirectional, periodic affective state transitions—remains poorly understood. In patients …
Relative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson's disease
Resting tremor (RT) is a Parkinson's disease (PD) symptom with an unclear relationship to
the dopaminergic system. We analysed data from 432 subjects from the Parkinson's …
the dopaminergic system. We analysed data from 432 subjects from the Parkinson's …
Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits
Balanced activity of canonical direct D1 and indirect D2 basal ganglia pathways is
considered a core requirement for normal movement, and their imbalance is an etiologic …
considered a core requirement for normal movement, and their imbalance is an etiologic …
Distributional coding of associative learning in discrete populations of midbrain dopamine neurons
R Avvisati, AK Kaufmann, CJ Young, GE Portlock… - Cell reports, 2024 - cell.com
Midbrain dopamine neurons are thought to play key roles in learning by conveying the
difference between expected and actual outcomes. Recent evidence suggests diversity in …
difference between expected and actual outcomes. Recent evidence suggests diversity in …
Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons
P Rajebhosale, MR Ananth, R Kim, R Crouse, L Jiang… - Elife, 2024 - elifesciences.org
Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SI
p) comprise the major source of cholinergic input to the basolateral amygdala (BLA). Using a …
p) comprise the major source of cholinergic input to the basolateral amygdala (BLA). Using a …