Bee venom and its active component Melittin synergistically potentiate the anticancer effect of Sorafenib against HepG2 cells

GH Mansour, MA El-Magd, DH Mahfouz… - Bioorganic …, 2021 - Elsevier
There are current attempts to find a safe substitute or adjuvant for Sorafenib (Sorf), the
standard treatment for advanced hepatocellular carcinoma (HCC), as it triggers very harsh …

Probiotic Properties of Bacillus proteolyticus Isolated From Tibetan Yaks, China

Z Zeng, X He, F Li, Y Zhang, Z Huang, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Yaks (Bos grunniens) live primarily in high-altitude hypoxic conditions and have a unique
intestinal micro-ecosystem, remarkable adaptability, and strong climatic resistance …

[HTML][HTML] Targeting c-Met in breast cancer: From mechanisms of chemoresistance to novel therapeutic strategies

EEJ Iweala, DN Amuji, AM Oluwajembola… - Current Research in …, 2024 - Elsevier
Breast cancer presents a significant challenge due to its heterogeneity and propensity for
developing chemoresistance, particularly in the triple-negative subtype. c-Mesenchymal …

Toxicoproteomics disclose pesticides as downregulators of TNF-α, IL-1β and estrogen receptor pathways in breast cancer women chronically exposed

L Pizzatti, ACB Kawassaki, B Fadel… - Frontiers in …, 2020 - frontiersin.org
Deleterious effects have been widely associated with chronic pesticide exposure, including
cancer development. In spite of several known consequences that pesticides can trigger in …

MORC4 Promotes Chemoresistance of Luminal A/B Breast Cancer via STAT3-Mediated MID2 Upregulation

J Luo, S Zeng, C Tian - OncoTargets and therapy, 2020 - Taylor & Francis
Purpose MORC4 has recently been characterized as a breast cancer-associated anti-
apoptotic oncoprotein. In the current study, we explored its downstream regulation in luminal …

Advances in the application of label‐free quantitative proteomics techniques in malignancy research

X Meng, D Liu, Y Guan - Biomedical Chromatography, 2023 - Wiley Online Library
Proteomics is the scientific discipline that deals with the protein composition of cells, tissues,
and organisms and their patterns of change. It is considered an invaluable tool for tackling …

Clinical implications of lipid peroxides levels in plasma and tumor tissue in breast cancer patients

TB Scandolara, JC da Silva, FM Alves… - Prostaglandins & Other …, 2022 - Elsevier
Oxidative stress can promote the oxidation of lipoproteins and polyunsaturated fatty acids
present in cell membranes; an event known as lipid peroxidation (LPO). LPO has been …

Predictive miRNAs Patterns in Blood of Breast Cancer Patients Demonstrating Resistance Towards Neoadjuvant Chemotherapy

J Fan, Y Tang, K Wang, S Yang… - Breast Cancer: Targets and …, 2023 - Taylor & Francis
Objective The effect of chemotherapy in patients with breast cancer (BC) is uncertain. This
study attempted to analyze serum microRNAs (miRNAs) in NAC resistant and sensitive BC …

[HTML][HTML] Secondary Analysis of Human Bulk RNA-Seq Dataset Suggests Potential Mechanisms for Letrozole Resistance in Estrogen-Positive (ER+) Breast Cancer

L Sutherland, J Lang, N Gonzalez-Juarbe… - Current Issues in …, 2024 - mdpi.com
Estrogen receptor-positive (ER+) breast cancer is common among postmenopausal women
and is frequently treated with Letrozole, which inhibits aromatase from synthesizing estrogen …

Long-term cadmium exposure induces epithelial-mesenchymal transition in breast cancer cells by activating CYP1B1-mediated glutamine metabolic reprogramming …

J Li, P Gao, M Qin, J Wang, Y Luo, P Deng… - Science of The Total …, 2024 - Elsevier
Cadmium (Cd) exposure is known to enhance breast cancer (BC) progression. Cd promotes
epithelial–mesenchymal transition (EMT) in BC cells, facilitating BC cell aggressiveness and …