Aberrant DNA methylation plays a pivotal role in tumor development and progression. DNA
hypomethylating agents (HMA) constitute a class of drugs which are able to reverse DNA …

Graft versus host disease (GVHD) is a common complication and the leading cause of
morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT) …

PURPOSE Relapse is a major cause of treatment failure after allogeneic hematopoietic stem-
cell transplantation (allo-HSCT) for high-risk acute myeloid leukemia (HR-AML). The aim of …

Thirty patients, with high-risk acute myeloid leukemia (AML, n= 20) or myelodysplastic
syndrome (MDS, n= 10), were enrolled in a phase II trial entailing prophylactic post …

Allogeneic stem cell transplantation (allo-SCT) is a curable method for the treatment of
hematological malignancies. In the past two decades, the establishment of haploidentical …

The therapeutic benefits of allogeneic hematopoietic stem cell transplantation (allo-HSCT)
are derived from the graft-versus-leukemia (GvL) effects of the procedure. There is a strong …

Regulatory T cells (Tregs) exert a highly suppressive function in the immune system.
Disturbances in their function predispose an individual to autoimmune dysregulation, with a …

DNA methyltransferase 3a (DNMT3a) is an important part of the epigenetic machinery that
stabilizes patterns of activated T cell responses. We hypothesized that donor T cell DNMT3a …

In the last twenty years, we have witnessed a paradigm shift in the treatment and prognosis
of acute myeloid leukemia (AML), thanks to the introduction of new efficient drugs or …

The field of epigenetics studies the complex processes that regulate gene expression
without altering the DNA sequence itself. It is well established that epigenetic modifications …