Environmental risks of pharmaceutical mixtures in aquatic ecosystems: Reflections on a decade of research

KA Kidd, T Backhaus, T Brodin… - Environmental …, 2024 - Wiley Online Library
Pharmaceuticals and personal care products (PPCPs) occur as variable mixtures in surface
waters receiving discharges of human and animal wastes. A key question identified a …

Towards precision ecotoxicology: Leveraging evolutionary conservation of pharmaceutical and personal care product targets to understand adverse outcomes across …

BW Brooks, S van den Berg, DA Dreier… - Environmental …, 2024 - Wiley Online Library
Translation of environmental science to the practice aims to protect biodiversity and
ecosystem services, and our future ability to do so relies on the development of a precision …

Pharmaceuticals and personal care products in the environment: What progress has been made in addressing the big research questions?

ABA Boxall, BW Brooks - Environmental Toxicology and …, 2024 - academic.oup.com
Alistair BA Boxalla,* and Bryan W. Brooksb aDepartment of Environment and Geography,
University of York, York, United Kingdom bDepartment of Environmental Science, Center for …

Cross‐species extrapolation of biological data to guide the environmental safety assessment of pharmaceuticals—The state of the art and future priorities

L Margiotta‐Casaluci, SF Owen… - Environmental …, 2024 - Wiley Online Library
The extrapolation of biological data across species is a key aspect of biomedical research
and drug development. In this context, comparative biology considerations are applied with …

[HTML][HTML] The use of fish cell lines as in-vitro ecotoxicological tools: A cellular solution to aquaculture sustainability

TV Nguyen, A Kumar, PN Trang - Aquaculture, 2024 - Elsevier
Aquaculture plays a crucial role in meeting the growing demand for seafood worldwide.
However, the sustainability of aquaculture practices faces challenges from environmental …

Establishing a NexGen, mechanism‐based environmental risk assessment paradigm shift: Are we ready yet?

C Rivetti, B Campos - Integrated Environmental Assessment …, 2023 - search.ebscohost.com
Establishing a NexGen, mechanism-based environmental risk assessment paradigm shift:
Are we ready yet? Traditional (eco) toxicology has reached a tipping point, with the historical …

[HTML][HTML] Cytotoxicity of Pharmaceuticals and Their Mixtures Toward Scaffold-Free 3D Spheroid Cultures of Rainbow trout (Oncorhynchus mykiss) Hepatocytes

P Järvinen, M Kakko, T Sikanen - European Journal of Pharmaceutical …, 2024 - Elsevier
Pharmaceutical residues are widely detected in surface waters all around the world, causing
a range of adverse effects on environmental species, such as fish. Besides population level …

Daphnids can safeguard the use of alternative bioassays to the acute fish toxicity test: A focus on neurotoxicity

C Schür, M Paparella, C Faßbender… - Environmental …, 2025 - academic.oup.com
Assessment of potential impacts of chemicals on the environment traditionally involves
regulatory standard data requirements for acute aquatic toxicity testing using algae …

Use of Alternatives to Animal Testing for Environmental Safety Assessment (ESA): Report from the 2023 EPAA Partners' Forum

JV Tarazona, A Fernandez-Agudo… - Regulatory Toxicology …, 2025 - Elsevier
Abstract Environmental Safety Assessments (ESA) are mandatory for several regulatory
purposes and are an important component of stewardship/sustainability initiatives. Fish …

[HTML][HTML] Miniaturizing Nanotoxicity Assays in Daphnids

D Kakavas, K Panagiotidis, KD Rochfort, K Grintzalis - Animals, 2024 - mdpi.com
Simple Summary Applications of nanoparticles as well as their use have increased over the
past decades without sufficient research on their environmental impact. Focusing on …