The origin and pathogenesis of endometriosis
Recent molecular genetic findings on endometriosis and normal endometrium suggest a
modified model in which circulating epithelial progenitor or stem cells intended to …
modified model in which circulating epithelial progenitor or stem cells intended to …
[HTML][HTML] Mesenchymal stem cells: key players in cancer progression
SM Ridge, FJ Sullivan, SA Glynn - Molecular cancer, 2017 - Springer
Tumour progression is dependent on the interaction between tumour cells and cells of the
surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell …
surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell …
[HTML][HTML] Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in …
Background Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa)
progression and dissemination. Insight in cell-to-cell communication networks provides new …
progression and dissemination. Insight in cell-to-cell communication networks provides new …
[HTML][HTML] Cytokines and chemokines as mediators of prostate cancer metastasis
TO Adekoya, RM Richardson - International journal of molecular sciences, 2020 - mdpi.com
The consequences of prostate cancer metastasis remain severe, with huge impact on the
mortality and overall quality of life of affected patients. Despite the convoluted interplay and …
mortality and overall quality of life of affected patients. Despite the convoluted interplay and …
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
Translational regulation plays a critical role in the control of cell growth and proliferation. A
key player in translational control is eIF4E, the mRNA 5′ cap-binding protein. Aberrant …
key player in translational control is eIF4E, the mRNA 5′ cap-binding protein. Aberrant …
NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation
Cancer cell molecular mimicry of stem cells (SC) imbues neoplastic cells with enhanced
proliferative and renewal capacities. In support, numerous mediators of SC self-renewal …
proliferative and renewal capacities. In support, numerous mediators of SC self-renewal …
[HTML][HTML] Radiogenomic mapping of edema/cellular invasion MRI-phenotypes in glioblastoma multiforme
Background Despite recent discoveries of new molecular targets and pathways, the search
for an effective therapy for Glioblastoma Multiforme (GBM) continues. A newly emerged field …
for an effective therapy for Glioblastoma Multiforme (GBM) continues. A newly emerged field …
CXCR4 and cancer
B Furusato, JS Rhim - Chemokine Receptors in Cancer, 2009 - Springer
The chemokine receptor CXCR4 belongs to the large superfamily of G-protein-coupled
receptors, and is directly involved in a number of biological processes including …
receptors, and is directly involved in a number of biological processes including …
Inflammatory cell infiltration of tumors: Jekyll or Hyde
JE Talmadge, M Donkor, E Scholar - Cancer and Metastasis Reviews, 2007 - Springer
Inflammatory cell infiltration of tumors contributes either positively or negatively to tumor
invasion, growth, metastasis, and patient outcomes, creating a Dr. Jekyll or Mr. Hyde …
invasion, growth, metastasis, and patient outcomes, creating a Dr. Jekyll or Mr. Hyde …
Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis
The chemokine stroma-derived factor (SDF-1/CXCL12) plays multiple roles in tumor
pathogenesis. It has been demonstrated that CXCL12 promotes tumor growth and …
pathogenesis. It has been demonstrated that CXCL12 promotes tumor growth and …