The yin and yang of pneumolysin during pneumococcal infection
JM Pereira, S Xu, JM Leong, S Sousa - Frontiers in immunology, 2022 - frontiersin.org
Pneumolysin (PLY) is a pore-forming toxin produced by the human pathobiont
Streptococcus pneumoniae, the major cause of pneumonia worldwide. PLY, a key …
Streptococcus pneumoniae, the major cause of pneumonia worldwide. PLY, a key …
Interaction of macrophages and cholesterol-dependent cytolysins: the impact on immune response and cellular survival
Cholesterol-dependent cytolysins (CDCs) are key virulence factors involved in many lethal
bacterial infections, including pneumonia, necrotizing soft tissue infections, bacterial …
bacterial infections, including pneumonia, necrotizing soft tissue infections, bacterial …
Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity
SF Erttmann, NO Gekara - Nature Communications, 2019 - nature.com
Abstract Hydrogen peroxide (H2O2) has a major function in host-microbial interactions.
Although most studies have focused on the endogenous H2O2 produced by immune cells to …
Although most studies have focused on the endogenous H2O2 produced by immune cells to …
The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity
LK Shewell, RM Harvey, MA Higgins… - Proceedings of the …, 2014 - National Acad Sciences
The cholesterol-dependent cytolysin (CDC) pneumolysin (Ply) is a key virulence factor of
Streptococcus pneumoniae. Membrane cholesterol is required for the cytolytic activity of this …
Streptococcus pneumoniae. Membrane cholesterol is required for the cytolytic activity of this …
[HTML][HTML] Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia
Streptococcus pneumoniae is responsible for significant mortality and morbidity worldwide
and causes invasive pneumococcal diseases including pneumococcal meningitis …
and causes invasive pneumococcal diseases including pneumococcal meningitis …
Epigallocatechin gallate inhibits Streptococcus pneumoniae virulence by simultaneously targeting pneumolysin and sortase A
M Song, Z Teng, M Li, X Niu, J Wang… - Journal of Cellular and …, 2017 - Wiley Online Library
Streptococcus pneumoniae (pneumococcus), the causative agent of several human
diseases, possesses numerous virulence factors associated with pneumococcal infection …
diseases, possesses numerous virulence factors associated with pneumococcal infection …
Influenza A virus infection predisposes hosts to secondary infection with different Streptococcus pneumoniae serotypes with similar outcome but serotype-specific …
N Sharma-Chawla, V Sender, O Kershaw… - Infection and …, 2016 - Am Soc Microbiol
Influenza A virus (IAV) and Streptococcus pneumoniae are major causes of respiratory tract
infections, particularly during coinfection. The synergism between these two pathogens is …
infections, particularly during coinfection. The synergism between these two pathogens is …
Multifaceted role of pneumolysin in the pathogenesis of myocardial injury in community-acquired pneumonia
Pneumolysin (PLY), a member of the family of Gram-positive bacterial, cholesterol-
dependent, β-barrel pore-forming cytolysins, is the major protein virulence factor of the …
dependent, β-barrel pore-forming cytolysins, is the major protein virulence factor of the …
Quercetin, a pneumolysin inhibitor, protects mice against Streptococcus pneumoniae infection
Q Lv, P Zhang, P Quan, M Cui, T Liu, Y Yin, G Chi - Microbial pathogenesis, 2020 - Elsevier
Abstract Pneumolysin (PLY), a pore-forming cytotoxin and a major virulence determinant, is
a member of the cholesterol-dependent cytolysin (CDC) family and essential for promoting …
a member of the cholesterol-dependent cytolysin (CDC) family and essential for promoting …
Impact of viral upper respiratory tract infection on the concentration of nasopharyngeal pneumococcal carriage among Kenyan children
Viral upper respiratory tract infection (URTI) predisposes to bacterial pneumonia possibly by
facilitating growth of bacteria such as Streptococcus pneumoniae colonising the …
facilitating growth of bacteria such as Streptococcus pneumoniae colonising the …