Membrane-intercalating conjugated oligoelectrolytes

C Zhou, GWN Chia, KT Yong - Chemical Society Reviews, 2022 - pubs.rsc.org
By acting as effective biomimetics of the lipid bilayers, membrane-intercalating conjugated
oligoelectrolytes (MICOEs) can spontaneously insert themselves into both synthetic lipid …

Multi-armed antibiotics for Gram-positive bacteria

Y Jia, W Chen, R Tang, J Zhang, X Liu, R Dong, F Hu… - Cell Host & Microbe, 2023 - cell.com
Antibiotic resistance is a serious threat to public health. Here, we propose a multi-armed
chemical scaffold (MACS) for antibiotic screening, which refers to multi-armed molecules …

A broad-spectrum synthetic antibiotic that does not evoke bacterial resistance

DM Heithoff, SP Mahan, L Barnes, SA Leyn… - …, 2023 - thelancet.com
Background Antimicrobial resistance (AMR) poses a critical threat to public health and
disproportionately affects the health and well-being of persons in low-income and middle …

Conjugated polymers for combatting antimicrobial resistance

Z Wang, H Geng, C Nie, C Xing - Chinese Journal of Chemistry, 2022 - Wiley Online Library
Comprehensive Summary Antimicrobial resistance (AMR) is one of the major challenges in
pathogenic infections, which endangers human health and brings devastating public health …

An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus

K Zhang, J Limwongyut, AS Moreland… - Science Translational …, 2024 - science.org
Infections caused by nontuberculous mycobacteria have increased more than 50% in the
past two decades and more than doubled in the elderly population. Mycobacterium …

Predicting antimicrobial activity of conjugated oligoelectrolyte molecules via machine learning

A Tiihonen, SJ Cox-Vazquez, Q Liang… - Journal of the …, 2021 - ACS Publications
New antibiotics are needed to battle growing antibiotic resistance, but the development
process from hit, to lead, and ultimately to a useful drug takes decades. Although progress in …

Cationic Lignin as an Efficient and Biorenewable Antimicrobial Material

K Acurio Cerda, M Kathol, G Purohit… - ACS Sustainable …, 2023 - ACS Publications
In this work, we utilized an inexpensive and naturally abundant polymer lignin and
functionalized it with quaternary ammonium groups to yield a cationic antimicrobial, QAL. As …

Real-Time Monitoring of Mitochondrial Damage Using Conjugated Oligoelectrolytes

SJW Chan, JY Zhu, WW Mia Soh… - Journal of the American …, 2023 - ACS Publications
Conjugated oligoelectrolytes (COEs) comprise a class of fluorescent reporters with tunable
optical properties and lipid bilayer affinity. These molecules have proven effective in a range …

Property regulation of conjugated oligoelectrolytes with polyisocyanide to achieve efficient photodynamic antibacterial biomimetic hydrogels

C Du, D Gao, M Gao, H Yuan, X Liu… - … Applied Materials & …, 2021 - ACS Publications
Fabricating antibacterial hydrogels with antimicrobial drugs and synthetic biocompatible
biomimetic hydrogels is a promising strategy for practical medical applications. Here, we …

Photophysics of Conjugated Oligoelectrolytes Relevant to Two‐Photon Fluorescence‐Lifetime Imaging Microscopy

JY Zhu, A Mikhailovsky, SCJ Wei… - Advanced Functional …, 2023 - Wiley Online Library
Conjugated oligoelectrolytes (COEs) comprise a class of cell‐membrane intercalating
molecules that serve as effective optical reporters. However, little is known about the …