The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Telomeres are the components of chromosome ends that provide stability and allow the
complete replication of the ends. Telomere length is maintained by a balance between …

▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …

It has been puzzling that mammalian telomeric proteins, including TRF1, TRF2, tankyrase,
and TIN2 have no recognized orthologs in budding yeast. Here, we describe a human …

Telomeres are the protein-DNA structures at the ends of eukaryotic chromosomes. In yeast,
and probably most other eukaryotes, telomeres are essential. They allow the cell to …

The maintenance of transcriptional silencing at HM mating-type loci and telomeres in yeast
requires the SIR2, SIR3, and SIR4 proteins, none of which appear to be DNA-binding …

In the yeast Saccharomyces cerevisiae, telomere elongation is negatively regulated by the
telomere repeat-binding protein Rap1p, such that a narrow length distribution of telomere …

The Saccharomyces cerevisiae Rap1 protein binds with high affinity to sites within the poly
(C (1-3) A) tracts at telomeres, where it plays a role in both telomere length regulation and …

TRF1 is a mammalian telomeric protein that binds to the duplex array of TTAGGG repeats at
chromosome ends. TRF1 has homology to the DNA‐binding domain of the Myb family of …

We have developed a novel technique for combined immunofluorescence/in situ
hybridization on fixed budding yeast cells that maintains the three-dimensional structure of …