Glucocorticoids and cognitive function: a walkthrough in endogenous and exogenous alterations
D De Alcubierre, D Ferrari, G Mauro, AM Isidori… - Journal of …, 2023 - Springer
Purpose The hypothalamic–pituitary–adrenal (HPA) axis exerts many actions on the central
nervous system (CNS) aside from stress regulation. Glucocorticoids (GCs) play an important …
nervous system (CNS) aside from stress regulation. Glucocorticoids (GCs) play an important …
Hormonal regulation of oligodendrogenesis I: effects across the lifespan
The brain's capacity to respond to changing environments via hormonal signaling is critical
to fine-tuned function. An emerging body of literature highlights a role for myelin plasticity as …
to fine-tuned function. An emerging body of literature highlights a role for myelin plasticity as …
[HTML][HTML] Plasma and fecal metabolite profiles in autism spectrum disorder
BD Needham, MD Adame, G Serena, DR Rose… - Biological …, 2021 - Elsevier
Background Autism spectrum disorder (ASD) is a neurodevelopmental condition with
hallmark behavioral manifestations including impaired social communication and restricted …
hallmark behavioral manifestations including impaired social communication and restricted …
Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women
Excitation-inhibition (E: I) imbalance is theorized as an important pathophysiological
mechanism in autism. Autism affects males more frequently than females and sex-related …
mechanism in autism. Autism affects males more frequently than females and sex-related …
The link between autism and sex-related neuroanatomy, and associated cognition and gene expression
Objective: The male preponderance in prevalence of autism is among the most pronounced
sex ratios across neurodevelopmental conditions. The authors sought to elucidate the …
sex ratios across neurodevelopmental conditions. The authors sought to elucidate the …
Dissecting the autism-associated 16p11. 2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein
PF Kretz, C Wagner, A Mikhaleva, C Montillot, S Hugel… - Genome Biology, 2023 - Springer
Background Using mouse genetic studies and systematic assessments of brain
neuroanatomical phenotypes, we set out to identify which of the 30 genes causes brain …
neuroanatomical phenotypes, we set out to identify which of the 30 genes causes brain …
Autism-related transcription factors underlying the sex-specific effects of prenatal bisphenol a exposure on transcriptome-interactome profiles in the offspring prefrontal …
S Kanlayaprasit, S Thongkorn, P Panjabud… - International Journal of …, 2021 - mdpi.com
Bisphenol A (BPA) is an environmental risk factor for autism spectrum disorder (ASD). BPA
exposure dysregulates ASD-related genes in the hippocampus and neurological functions …
exposure dysregulates ASD-related genes in the hippocampus and neurological functions …
Novel mutations in NLGN3 causing autism spectrum disorder and cognitive impairment
A Quartier, J Courraud, T Thi Ha, G McGillivray… - Human …, 2019 - Wiley Online Library
The X‐linked NLGN3 gene, encoding a postsynaptic cell adhesion molecule, was involved
in a nonsyndromic monogenic form of autism spectrum disorder (ASD) by the description of …
in a nonsyndromic monogenic form of autism spectrum disorder (ASD) by the description of …
Androgens increase excitatory neurogenic potential in human brain organoids
The biological basis of male–female brain differences has been difficult to elucidate in
humans. The most notable morphological difference is size, with male individuals having on …
humans. The most notable morphological difference is size, with male individuals having on …
Rare de novo missense variants in RNA helicase DDX6 cause intellectual disability and dysmorphic features and lead to P-body defects and RNA dysregulation
The human RNA helicase DDX6 is an essential component of membrane-less organelles
called processing bodies (PBs). PBs are involved in mRNA metabolic processes including …
called processing bodies (PBs). PBs are involved in mRNA metabolic processes including …