Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an
increased possibility of adverse consequences such as falls, fractures, physical disabilities …

The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of
time for the organism. The synchrony between the daily challenges imposed by the …

Accumulating evidence indicates that obesity with its associated metabolic dysregulation,
including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of …

Longitudinal studies associate shiftwork with cardiometabolic disorders but do not establish
causation or elucidate mechanisms of disease. We developed a mouse model based on …

Time-restricted feeding (TRF) is a nutritional intervention wherein food intake is limited to a
consistent 8-to 10-h daily window without changes in nutritional quality or quantity. TRF can …

Circadian rhythms are~ 24 h cycles of behavior and physiology that are generated by a
network of molecular clocks located in nearly every tissue in the body. In mammals, the …

This review focuses on the question of metabolic syndrome (MS) being a complex, but
essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of …

Calorie restriction is a primary dietary intervention demonstrated over many decades in
cellular and animal models to modulate aging pathways, positively affect age-associated …

Obesity occurs when energy expenditure is outweighed by energy intake. Tuberal
hypothalamic nuclei, including the arcuate nucleus (ARC), ventromedial nucleus (VMH), and …

Increasing evidence indicates that disturbance of the clock genes, which leads to systemic
endocrine perturbation, plays a crucial role in the pathogenesis of metabolic and liver …