Plant-derived anticancer compounds as new perspectives in drug discovery and alternative therapy
CA Dehelean, I Marcovici, C Soica, M Mioc… - Molecules, 2021 - mdpi.com
Despite the recent advances in the field of chemically synthetized pharmaceutical agents,
nature remains the main supplier of bioactive molecules. The research of natural products is …
nature remains the main supplier of bioactive molecules. The research of natural products is …
Cyclodextrins and their derivatives as drug stability modifiers
Cyclodextrins (CDs) are cyclic oligosaccharides that contain a relatively hydrophobic central
cavity and a hydrophilic outer surface. They are widely used to form non-covalent inclusion …
cavity and a hydrophilic outer surface. They are widely used to form non-covalent inclusion …
Inhalable resveratrol-cyclodextrin complex loaded biodegradable nanoparticles for enhanced efficacy against non-small cell lung cancer
Resveratrol (RES), a natural polyphenol in fruits, has shown promising anti-cancer
properties. Due to its relative low toxicity which limits the adverse effects observed for …
properties. Due to its relative low toxicity which limits the adverse effects observed for …
Prospects of charged cyclodextrins in biomedical applications
Cyclodextrins (CDs), recognized for their unique ability to form inclusion complexes, have
seen broad utilization across various scientific fields. Recently, there has been a surge of …
seen broad utilization across various scientific fields. Recently, there has been a surge of …
Resveratrol-loaded nanocarriers: Characteristics, sources, health effects, recent delivery systems, and their food and biomedical applications
Abstract Resveratrol (3, 5, 4′-trihydroxystilbene, RES) is a polyphenolic phytoalexin widely
studied in the recent years due to its known several biological activities. In spite of the …
studied in the recent years due to its known several biological activities. In spite of the …
Enhanced solubility, stability, permeation and anti-cancer efficacy of Celastrol-β-cyclodextrin inclusion complex
SK Shukla, A Chan, V Parvathaneni… - Journal of Molecular …, 2020 - Elsevier
Celastrol (Cela), a pentacyclic triterpenoid, has been explored widely due to its broad
therapeutic activity such as antioxidant, chemotherapeutic, neuroprotective etc. However …
therapeutic activity such as antioxidant, chemotherapeutic, neuroprotective etc. However …
Thermal degradation of antioxidant compounds: Effects of parameters, thermal degradation kinetics, and formulation strategies
Stability of antioxidant compounds (AC) is always a challenging aspect in the food industry.
AC, by nature, can be easily degraded under exposure of different parameters …
AC, by nature, can be easily degraded under exposure of different parameters …
Repurposing bedaquiline for effective non-small cell lung cancer (NSCLC) therapy as inhalable cyclodextrin-based molecular inclusion complexes
There is growing evidence that repurposed drugs demonstrate excellent efficacy against
many cancers, while facilitating accelerated drug development process. In this study …
many cancers, while facilitating accelerated drug development process. In this study …
Development and characterization of inhaled nintedanib-loaded PLGA nanoparticles using scalable high-pressure homogenization technique
Presently, non-invasive targeted drug delivery to the lungs represents a routinely
investigated approach to treat challenging disorders such as pulmonary fibrosis. Nintedanib …
investigated approach to treat challenging disorders such as pulmonary fibrosis. Nintedanib …
Preparation and Characterisation of Zinc Diethyldithiocarbamate–Cyclodextrin Inclusion Complexes for Potential Lung Cancer Treatment
Zinc diethyldithiocarbamate (Zn (DDC) 2), a disulfiram metabolite (anti-alcoholism drug), has
shown a strong anti-cancer activity in vitro. However, its application was limited by its low …
shown a strong anti-cancer activity in vitro. However, its application was limited by its low …