The importance of indole and azaindole scaffold in the development of antitumor agents

Y Han, W Dong, Q Guo, X Li, L Huang - European journal of medicinal …, 2020 - Elsevier
With some indoles and azaindoles being successfully developed as anticancer drugs, the
design and synthesis of indole and azaindole derivatives with remarkable antitumor activity …

Insights into the structure activity relationship of nitrogen-containing heterocyclics for the development of antidepressant compounds: An updated review

K Singh, R Pal, SA Khan, B Kumar, MJ Akhtar - Journal of Molecular …, 2021 - Elsevier
Abstract According to the World Health Organization (WHO), depression is a common
mental disorder and includes complex interaction between social and psychological …

Design of a Schiff base complex of copper coated on epoxy-modified core–shell MNPs as an environmentally friendly and novel catalyst for the one-pot synthesis of …

S Rezayati, A Ramazani, S Sajjadifar… - ACS …, 2021 - ACS Publications
An ecofriendly inorganic–organic hybrid and novel Schiff base complex of copper coated on
epoxy-modified Fe3O4@ SiO2 MNPs was successfully designed and prepared from readily …

Facile and One-Pot Access to Diverse and Densely Functionalized 2-Amino-3-cyano-4H-pyrans and Pyran-Annulated Heterocyclic Scaffolds via an Eco-Friendly …

G Brahmachari, B Banerjee - ACS Sustainable Chemistry & …, 2014 - ACS Publications
A simple, straightforward, and highly efficient multicomponent one-pot synthesis of a
pharmaceutically interesting diverse kind of functionalized 2-amino-3-cyano-4 H-pyrans and …

Synthesis, biological activity and POM/DFT/docking analyses of annulated pyrano [2, 3-d] pyrimidine derivatives: Identification of antibacterial and antitumor …

AR Bhat, RS Dongre, FA Almalki, M Berredjem… - Bioorganic …, 2021 - Elsevier
Abstract New annulated pyrano [2, 3-d] pyrimidine derivatives were synthesized with
hydroxyl, methoxy, bromine, nitrile and nitro substituents on its skeleton. The correlated …

Electrochemical Selenylative Carbannulation of Biaryl Ynones to Seleno-Dibenzocycloheptenones/Spiro [5.5] Trienones

C Raji Reddy, DH Kolgave - The Journal of Organic Chemistry, 2021 - ACS Publications
Electrooxidative-induced synthesis of structurally diverse seleno-dibenzocyclohepten-5-
ones and seleno-spiro [5.5] trienones by selenylative carbannulation of biaryl ynones with …

Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …

Green synthetic approaches for biologically relevant 2-amino-4H-pyrans and 2-amino-4H-pyran-annulated heterocycles in aqueous media

G Brahmachari - Green synthetic approaches for biologically relevant …, 2021 - Elsevier
Abstract 4H-Pyrans and 4H-pyran-annulated heterocyclic scaffolds represent a “privileged”
structural motif well-distributed in biologically active natural products and also in promising …

Synthesis, molecular docking and antimicrobial activity of new fused pyrimidine and pyridine derivatives

MAA Radwan, MA Alshubramy, M Abdel-Motaal… - Bioorganic …, 2020 - Elsevier
Synthesis of some new heterocyclic ring systems incorporated pyrimidine and pyridine
moieties starting from 1-(furan-2-yl)-3-(thiophen-2-yl) chalcone was achieved. The structure …

Design, synthesis, molecular modeling and biological evaluation of novel 1H-pyrazolo [3, 4-b] pyridine derivatives as potential anticancer agents

IH Eissa, AM El-Naggar, MA El-Hashash - Bioorganic chemistry, 2016 - Elsevier
In trying to develop new anticancer agents, a series of 1H-pyrazolo [3, 4-b] pyridine
derivatives was designed and synthesized. Fifteen compounds were evaluated in vitro for …