Transcriptional response to hypoxia: the role of HIF-1-associated co-regulators
The Hypoxia Inducible Factor 1 (HIF-1) plays a major role in the cellular response to hypoxia
by regulating the expression of many genes involved in adaptive processes that allow cell …
by regulating the expression of many genes involved in adaptive processes that allow cell …
Integration of oxygen signaling at the consensus HRE
The hypoxia-inducible factor 1 (HIF-1) was initially identified as a transcription factor that
regulated erythropoietin gene expression in response to a decrease in oxygen availability in …
regulated erythropoietin gene expression in response to a decrease in oxygen availability in …
[HTML][HTML] Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
The pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the
PKM2 gene. PKM2, but not PKM1, alters glucose metabolism in cancer cells and contributes …
PKM2 gene. PKM2, but not PKM1, alters glucose metabolism in cancer cells and contributes …
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
J Schödel, S Oikonomopoulos… - Blood, The Journal …, 2011 - ashpublications.org
Hypoxia-inducible factor (HIF) regulates the major transcriptional cascade central to the
response of all mammalian cells to alterations in oxygen tension. Expression arrays indicate …
response of all mammalian cells to alterations in oxygen tension. Expression arrays indicate …
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials
TL Yeh, TM Leissing, MI Abboud, CC Thinnes… - Chemical …, 2017 - pubs.rsc.org
Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl
hydroxylases (human PHD1–3) causes upregulation of HIF, thus promoting erythropoiesis …
hydroxylases (human PHD1–3) causes upregulation of HIF, thus promoting erythropoiesis …
Regulation of hypoxia-inducible factor-1α by NF-κB
P van Uden, NS Kenneth, S Rocha - Biochemical Journal, 2008 - portlandpress.com
HIF (hypoxia-inducible factor) is the main transcription factor activated by low oxygen
tensions. HIF-1α (and other α subunits) is tightly controlled mostly at the protein level …
tensions. HIF-1α (and other α subunits) is tightly controlled mostly at the protein level …
Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development
Chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion,
characterized by expression of type X collagen (COL10A1), matrix metalloproteinase-13 …
characterized by expression of type X collagen (COL10A1), matrix metalloproteinase-13 …
Regulation of metabolism by hypoxia-inducible factor 1
GL Semenza - Cold Spring Harbor symposia on quantitative …, 2011 - symposium.cshlp.org
The maintenance of oxygen homeostasis is critical for survival, and the master regulator of
this process in metazoan species is hypoxia-inducible factor 1 (HIF-1), which controls both O …
this process in metazoan species is hypoxia-inducible factor 1 (HIF-1), which controls both O …
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia
The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a central role in the
transcriptional response to oxygen flux. To gain insight into the molecular pathways …
transcriptional response to oxygen flux. To gain insight into the molecular pathways …
Oxygen homeostasis
GL Semenza - Wiley Interdisciplinary Reviews: Systems Biology …, 2010 - Wiley Online Library
Metazoan life is dependent upon the utilization of O2 for essential metabolic processes and
oxygen homeostasis is an organizing principle for understanding metazoan evolution …
oxygen homeostasis is an organizing principle for understanding metazoan evolution …