Unpacking extracellular vesicles: RNA cargo loading and function

ER Dellar, C Hill, GE Melling… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are a heterogeneous group of membrane‐enclosed structures
produced by prokaryotic and eukaryotic cells. EVs carry a range of biological cargoes …

A task-specific encoding algorithm for RNAs and RNA-associated interactions based on convolutional autoencoder

Y Wang, Z Pan, M Mou, W Xia, H Zhang… - Nucleic acids …, 2023 - academic.oup.com
RNAs play essential roles in diverse physiological and pathological processes by interacting
with other molecules (RNA/protein/compound), and various computational methods are …

Phospholipid membranes as chemically and functionally tunable materials

D Huster, S Maiti, A Herrmann - Advanced Materials, 2024 - Wiley Online Library
The sheet‐like lipid bilayer is the fundamental structural component of all cell membranes.
Its building blocks are phospholipids and cholesterol. Their amphiphilic structure …

Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism

L Han, D Huang, S Wu, S Liu, C Wang, Y Sheng… - Nature cell …, 2023 - nature.com
Lipid droplets (LDs) are cellular organelles critical for lipid homeostasis, with intramyocyte
LD accumulation implicated in metabolic disorder-associated heart diseases. Here we …

Cyclophospholipids enable a protocellular life cycle

OD Toparlak, L Sebastianelli, V Egas Ortuno, M Karki… - ACS …, 2023 - ACS Publications
There is currently no plausible path for the emergence of a self-replicating protocell,
because prevalent formulations of model protocells are built with fatty acid vesicles that …

Robust and tunable performance of a cell-free biosensor encapsulated in lipid vesicles

MA Boyd, W Thavarajah, JB Lucks, NP Kamat - Science advances, 2023 - science.org
Cell-free systems have enabled the development of genetically encoded biosensors to
detect a range of environmental and biological targets. Encapsulation of these systems in …

Plant condensates: no longer membrane-less?

IH Hatzianestis, F Mountourakis, S Stavridou… - Trends in Plant …, 2023 - cell.com
Cellular condensation is a reinvigorated area of study in biology, with scientific discussions
focusing mainly on the forces that drive condensate formation, properties, and functions …

Periodic temperature changes drive the proliferation of self-replicating RNAs in vesicle populations

E Salibi, B Peter, P Schwille, H Mutschler - Nature Communications, 2023 - nature.com
Growth and division of biological cells are based on the complex orchestration of
spatiotemporally controlled reactions driven by highly evolved proteins. In contrast, it …

On the influence of nucleic acid backbone modifications on lipid nanoparticle morphology

K An, D Kurek, M Mahadeo, Y Zhang, JL Thewalt… - Langmuir, 2022 - ACS Publications
Nucleic acid therapeutics represent a major advance toward treating diseases at their root
cause. However, nucleic acids are prone to degradation by serum endonucleases …

Roles of G4-DNA and G4-RNA in class switch recombination and additional regulations in b-lymphocytes

O Dézé, B Laffleur, M Cogné - Molecules, 2023 - mdpi.com
Mature B cells notably diversify immunoglobulin (Ig) production through class switch
recombination (CSR), allowing the junction of distant “switch”(S) regions. CSR is initiated by …