Therapeutic strategies to ameliorate neuronal damage in epilepsy by regulating oxidative stress, mitochondrial dysfunction, and neuroinflammation

S Madireddy, S Madireddy - Brain sciences, 2023 - mdpi.com
Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures
that affects 50 million individuals globally. Because approximately one-third of patients with …

[HTML][HTML] Phytotherapy: A promising approach for the treatment of Alzheimer's disease

OO John, IS Amarachi, AP Chinazom, E Adaeze… - Pharmacological …, 2022 - Elsevier
Alzheimer's disease (AD) is a progressive neurological disease and the most common form
of dementia, affecting more than 10 million people all over the world. Clinically, AD is …

Navigating the Intersection: Diabetes and Alzheimer's Intertwined Relationship

MB Kale, HM Bhondge, NL Wankhede… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) and Diabetes mellitus (DM) exhibit comparable
pathophysiological pathways. Genetic abnormalities in APP, PS-1, and PS-2 are linked to …

[HTML][HTML] Involvement of molecular chaperone in protein-misfolding brain diseases

NL Wankhede, MB Kale, AB Upaganlawar… - Biomedicine & …, 2022 - Elsevier
Protein misfolding causes aggregation and build-up in a variety of brain diseases. There are
numeral molecules that are linked with the protein homeostasis mechanism. Molecular …

Mitochondrial dysfunction as a signaling target for therapeutic intervention in major neurodegenerative disease

SV Mangrulkar, NL Wankhede, MB Kale… - Neurotoxicity …, 2023 - Springer
Neurodegenerative diseases (NDD) are incurable and the most prevalent cognitive and
motor disorders of elderly. Mitochondria are essential for a wide range of cellular processes …

Role of Stat3 in NLRP3/caspase‐1‐mediated hippocampal neuronal pyroptosis in epileptic mice

Q Jiang, G Tang, XM Zhong, DR Ding, H Wang… - Synapse, 2021 - Wiley Online Library
Epilepsy, a fairly common neurological disorder, is linked to various sequelae and greatly
impairs the quality of life. Meanwhile, there is evidence to suggest an association between …

Neuroprotective effects of glucagon-like peptide-1 (GLP-1) analogues in epilepsy and associated comorbidities

MA Manavi - Neuropeptides, 2022 - Elsevier
Epilepsy is a common neurological condition induced by losing equilibrium of different
pathway as well as neurotransmitters that affects over 50 million people globally …

Molecular understanding of ER-MT communication dysfunction during neurodegeneration

SS Sammeta, TA Banarase, SR Rahangdale… - Mitochondrion, 2023 - Elsevier
Biological researchers are seeing organelles in a new light. These cellular entities have
been believed to be singular and distinctive structures that performed specialized purposes …

Unraveling the nexus of age, epilepsy, and mitochondria: exploring the dynamics of cellular energy and excitability

W Xie, S Koppula, MB Kale, LS Ali… - Frontiers in …, 2024 - frontiersin.org
Epilepsy, a complex neurological condition marked by recurring seizures, is increasingly
recognized for its intricate relationship with mitochondria, the cellular powerhouses …

Alzheimer's disease and sleep disorders: Insights into the possible disease connections and the potential therapeutic targets

VS Marde, UA Atkare, SV Gawali, PL Tiwari… - Asian Journal of …, 2022 - Elsevier
One of the comorbid conditions in an individual with Alzheimer's disease is a sleep disorder.
Clinical features of sleep disorders involve various sleep disturbances such as Obstructive …