AI on a chip

A Isozaki, J Harmon, Y Zhou, S Li, Y Nakagawa… - Lab on a Chip, 2020 - pubs.rsc.org
Artificial intelligence (AI) has dramatically changed the landscape of science, industry,
defence, and medicine in the last several years. Supported by considerably enhanced …

Computer vision meets microfluidics: a label-free method for high-throughput cell analysis

S Zhou, B Chen, ES Fu, H Yan - Microsystems & Nanoengineering, 2023 - nature.com
In this paper, we review the integration of microfluidic chips and computer vision, which has
great potential to advance research in the life sciences and biology, particularly in the …

Deep imaging flow cytometry

K Huang, H Matsumura, Y Zhao, M Herbig, D Yuan… - Lab on a Chip, 2022 - pubs.rsc.org
Imaging flow cytometry (IFC) has become a powerful tool for diverse biomedical applications
by virtue of its ability to image single cells in a high-throughput manner. However, there …

Toward deep biophysical cytometry: prospects and challenges

KCM Lee, J Guck, K Goda, KK Tsia - Trends in Biotechnology, 2021 - cell.com
The biophysical properties of cells reflect their identities, underpin their homeostatic state in
health, and define the pathogenesis of disease. Recent leapfrogging advances in …

Optofluidic imaging meets deep learning: from merging to emerging

DMD Siu, KCM Lee, BMF Chung, JSJ Wong, G Zheng… - Lab on a Chip, 2023 - pubs.rsc.org
Propelled by the striking advances in optical microscopy and deep learning (DL), the role of
imaging in lab-on-a-chip has dramatically been transformed from a silo inspection tool to a …

Virtual-freezing fluorescence imaging flow cytometry with 5-aminolevulinic acid stimulation and antibody labeling for detecting all forms of circulating tumor cells

H Matsumura, LTW Shen, A Isozaki, H Mikami, D Yuan… - Lab on a Chip, 2023 - pubs.rsc.org
Circulating tumor cells (CTCs) are precursors to cancer metastasis. In blood circulation, they
take various forms such as single CTCs, CTC clusters, and CTC–leukocyte clusters, all of …

Interpretable unsupervised learning enables accurate clustering with high-throughput imaging flow cytometry

Z Zhang, X Chen, R Tang, Y Zhu, H Guo, Y Qu, P Xie… - Scientific Reports, 2023 - nature.com
A primary challenge of high-throughput imaging flow cytometry (IFC) is to analyze the vast
amount of imaging data, especially in applications where ground truth labels are …

Low-latency label-free image-activated cell sorting using fast deep learning and AI inferencing

R Tang, L Xia, B Gutierrez, I Gagne, A Munoz… - Biosensors and …, 2023 - Elsevier
Classification and sorting of cells using image-activated cell sorting (IACS) systems can
bring significant insight to biomedical sciences. Incorporating deep learning algorithms into …

A high-throughput technique to map cell images to cell positions using a 3D imaging flow cytometer

Z Zhang, R Tang, X Chen, L Waller… - Proceedings of the …, 2022 - National Acad Sciences
We develop a high-throughput technique to relate positions of individual cells to their three-
dimensional (3D) imaging features with single-cell resolution. The technique is particularly …

Accessible high-speed image-activated cell sorting

TM Kuhn, M Paulsen, S Cuylen-Haering - Trends in Cell Biology, 2024 - cell.com
Over the past six decades, fluorescence-activated cell sorting (FACS) has become an
essential technology for basic and clinical research by enabling the isolation of cells of …