Abstract Iron-sulfur (Fe–S) clusters are essential cofactors most commonly known for their
role mediating electron transfer within the mitochondrial respiratory chain. The Fe–S cluster …

Mitochondria has an essential role in myocardial tissue homeostasis; thus deterioration in
mitochondrial function eventually leads to cardiomyocyte and endothelial cell death and …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Ventricular pressure–volume relationships have become well established as the most
rigorous and comprehensive ways to assess intact heart function. Thanks to advances in …

Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …

Doxorubicin (DOX) is a potent available antitumor agent; however, its clinical use is limited
because of its cardiotoxicity. Cell death is a key component in DOX-induced cardiotoxicity …

Purpose: One mechanism of tumor resistance to cytotoxic therapy is repair of damaged
DNA. Poly (ADP-ribose) polymerase (PARP)-1 is a nuclear enzyme involved in base …

Poly (ADP-ribosyl) ation is an immediate cellular repair response to DNA damage and is
catalyzed primarily by poly (ADP-ribose) polymerase-1 (PARP1), which is the most …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …