Integrins are a large family of extracellular matrix (ECM) receptors. In the developing and
adult brain, many integrins are present at high levels at synapses. The tetrapartite structure …

The neuropathology associated with Alzheimer's disease (AD) is characterized by the
presence of extracellularly neuritic plaques, intracellularly neurofibrillary tangles and the …

Synthetic amyloid-β protein (Aβ) oligomers bind with high affinity to cellular prion protein
(PrPC), but the role of this interaction in mediating the disruption of synaptic plasticity by …

Human Islet amyloid polypeptide (hIAPP) from pancreatic β cells in the islet of Langerhans
has different physiological functions including inhibiting the release of insulin and glucagon …

Alzheimer's disease (AD) is an incurable neurodegenerative disorder in which dysfunction
and loss of synapses and neurons lead to cognitive impairment and death. Accumulation …

We have tested a hypothesis that the natural product curcuminoids, which has
epidemiologic and experimental rationale for use in AD, may improve the innate immune …

Several neurological diseases, including Parkinson disease and dementia with Lewy
bodies, are characterized by the accumulation of α-synuclein phosphorylated at Ser-129 (p …

Background Alzheimer's disease (AD) is a complex, irreversible neurodegenerative
disorder. At present there are neither reliable markers to diagnose AD at an early stage nor …

A recent genome-wide association meta-analysis for Alzheimer's disease (AD) identified 19
risk loci (in addition to APOE) in which the functional genes are unknown. Using Drosophila …

Brain extracellular matrix (ECM) is a highly organized system that consists of collagens,
noncollagenous proteins, glycoproteins, hyaluronan, and proteoglycans. Recognized …