Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

Ulcerative colitis (UC) is driven by disruptions in host–microbiota homoeostasis, but current
treatments exclusively target host inflammatory pathways. To understand how host …

Background Uncontrolled seizures in patients with gliomas have a significant impact on
quality of life and morbidity, yet the mechanisms through which these tumors cause seizures …

The genetic abnormalities that drive tumorigenesis are usually coupled with epigenetic
alterations, such as DNA methylation and aberrant histone modifications, which may help …

Histone demethylase upregulation has been observed in human cancers, yet it is unknown
whether this is a bystander event or a driver of tumorigenesis. We found that overexpression …

Landmark discoveries made nearly two decades ago identified known transcriptional
regulators as histone lysine methyltransferases. Since then, the field of lysine methylation …

The KDM5/JARID1 family of Fe (II)-and α-ketoglutarate-dependent demethylases remove
methyl groups from tri-and dimethylated lysine 4 of histone H3. Accumulating evidence from …

The mediator complex-associated cyclin dependent kinase CDK8 regulates β-catenin-
dependent transcription following activation of WNT signaling. Multiple lines of evidence …

The histone lysine demethylase 4 (KDM4) family plays an important role in regulating gene
transcription, DNA repair, and metabolism. The dysregulation of KDM4 functions is …