Targeting the PDGF signaling pathway in tumor treatment

CH Heldin - Cell Communication and Signaling, 2013 - Springer
Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important
functions in the regulation of growth and survival of certain cell types during embryonal …

Regulation of dual-specificity phosphatase (DUSP) ubiquitination and protein stability

HF Chen, HC Chuang, TH Tan - International journal of molecular …, 2019 - mdpi.com
Mitogen-activated protein kinases (MAPKs) are key regulators of signal transduction and cell
responses. Abnormalities in MAPKs are associated with multiple diseases. Dual-specificity …

PDGF receptor signaling networks in normal and cancer cells

JB Demoulin, A Essaghir - Cytokine & growth factor reviews, 2014 - Elsevier
For about four decades, platelet-derived growth factors (PDGF) and their receptors have
been the subject of intense research, revealing their roles in embryo development and …

Involvement of platelet‐derived growth factor ligands and receptors in tumorigenesis

CH Heldin, J Lennartsson… - Journal of internal …, 2018 - Wiley Online Library
Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

O Bermudez, G Pagès… - American Journal of …, 2010 - journals.physiology.org
Intracellular signaling by mitogen-activated protein (MAP) kinases (MAPK) is involved in
many cellular responses and in the regulation of various physiological and pathological …

[HTML][HTML] Dual-specificity phosphatase 6 (DUSP6): a review of its molecular characteristics and clinical relevance in cancer

MK Ahmad, NA Abdollah, NH Shafie… - Cancer biology & …, 2018 - ncbi.nlm.nih.gov
Mitogen-activated protein kinases (MAPKs) are the main regulators of cellular proliferation,
growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling …

Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells

Z Zhang, S Kobayashi, AC Borczuk, RS Leidner… - …, 2010 - academic.oup.com
Mitogen-activated protein kinase (MAPK) pathway signaling plays an important role in the
majority of non-small-cell lung cancers (NSCLCs). In a prior microarray analysis of …

Angiogenesis: managing the culprits behind tumorigenesis and metastasis

AHS Yehya, M Asif, SH Petersen, AV Subramaniam… - Medicina, 2018 - mdpi.com
Deregulated angiogenesis has been identified as a key contributor in a number of
pathological conditions including cancer. It is a complex process, which involves highly …

Platelet-derived growth factor signaling in the lung. From lung development and disease to clinical studies

N Noskovičová, M Petřek, O Eickelberg… - American journal of …, 2015 - atsjournals.org
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) represent one of the
most intensively studied families of growth factors in the last four decades. PDGF signaling …

A streamlined tandem tip-based workflow for sensitive nanoscale phosphoproteomics

CF Tsai, YT Wang, CC Hsu, RB Kitata, RK Chu… - Communications …, 2023 - nature.com
Effective phosphoproteome of nanoscale sample analysis remains a daunting task, primarily
due to significant sample loss associated with non-specific surface adsorption during …