The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Mechanisms that integrate the metabolic state of a cell with regulatory pathways are
necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites …

Glucose is the main energy substrate for the brain. There is now extensive evidence
indicating that the metabolic profile of neural cells with regard to glucose utilization and …

Significance: The mitochondrial matrix contains much of the machinery at the heart of
metabolism. This compartment is also exposed to a high and continual flux of superoxide …

Methylglyoxal (MG), a cytotoxic by-product produced mainly from triose phosphates, is used
as a substrate by glyoxalase I. In this paper, we report on the estimation of MG level in plants …

The discovery of the enzymatic formation of lactic acid from methylglyoxal dates back to
1913 and was believed to be associated with one enzyme termed ketonaldehydemutase or …

Methylglyoxal (MG), an endogenous metabolite that increases in diabetes and is a common
intermediate in the Maillard reaction (glycation), reacts with proteins and forms advanced …

Cellular proteins continuously undergo non-enzymatic covalent modifications (NECMs) that
accumulate under normal physiological conditions and are stimulated by changes in the …

Advanced glycation end-products (AGEs) are the final products of the non-enzymatic
reaction between reducing sugars and amino groups in proteins, lipids and nucleic acids …