A transmembrane protein (TMEM) is a type of protein that spans biological membranes.
Many of them extend through the lipid bilayer of the plasma membrane but others are …

Recently, it has been shown that oncogene-induced senescence (OIS) occurs during the
early stages of tumorigenesis. Senescent tumour cells are abundant within premalignant …

Background Endometriosis is a common, complex disorder which is underrecognized and
subject to prolonged delays in diagnosis. It is accompanied by significant changes in the …

We have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras V12
oncoprotein along with a marker protein (β-geo) from a single bicistronic transcript …

Normal human fibroblasts undergo a limited number of divisions in culture and progressively
they reach a state of irreversible growth arrest, a process termed as replicative senescence …

Human cells in culture have a limited proliferative capacity. After a period of vigorous
proliferation, the rate of cell division declines and a number of changes occur in the cells …

The serrated polyp pathway is a histopathological sequence that begins in a hyperplastic
polyp, or precursor serrated aberrant crypt focus, and has the potential to end in a colonic …

Glioblastoma is the most common primary intracranial malignant tumor in adults and has
high morbidity and high mortality. TMEM158 has been reported to promote the progression …

Dupuytren's disease is characterized by nodule formation and contracture of the palmar
fascia, resulting in flexion deformity of the fingers and loss of hand function. The authors …

Although ras is a potent mitogenic oncogene, its tumorigenicity depends on cellular context
and cooperative events. Here we show that low-level expression of a constitutively active Ha …