Ginsenoside Rb1 as an anti-diabetic agent and its underlying mechanism analysis

P Zhou, W Xie, S He, Y Sun, X Meng, G Sun, X Sun - Cells, 2019 - mdpi.com
Panax ginseng and Panax notoginseng, two well-known medical plants with economic
value, have a long history of use for managing various diseases in Asian countries …

The role of the PI3K/AKT/mTOR signalling pathway in male reproduction

CY Deng, M Lv, BH Luo, SZ Zhao… - Current molecular …, 2021 - ingentaconnect.com
Male fertility is closely related to the normal function of the hypothalamicpituitary-testicular
axis. The testis is an important male reproductive organ that secretes androgen and …

Obesity-mediated immune modulation: one step forward,(Th) 2 steps back

V Schmidt, AE Hogan, PG Fallon… - Frontiers in …, 2022 - frontiersin.org
Over the past decades, the relationship between the immune system and metabolism has
become a major research focus. In this arena of immunometabolism the capacity of adipose …

Multiple leptin signalling pathways in the control of metabolism and fertility: a means to different ends?

MC Evans, RA Lord, GM Anderson - International Journal of Molecular …, 2021 - mdpi.com
The adipocyte-derived 'satiety promoting'hormone, leptin, has been identified as a key
central regulator of body weight and fertility, such that its absence leads to obesity and …

Unraveling molecular signatures in rare bone tumors and navigating the cancer pathway landscapes for targeted therapeutics

AK Wani, A Prakash, S Sena, N Akhtar, R Singh… - Critical Reviews in …, 2024 - Elsevier
Rare cancers (RCs), which account for over 20% of cancer cases, face significant research
and treatment challenges due to their limited prevalence. This results in suboptimal …

Breast feeding, obesity, and asthma association: clinical and molecular views

N Kian, A Bagheri, F Salmanpour, A Soltani… - Clinical and molecular …, 2023 - Springer
Asthma is a chronic condition that affects children worldwide. Accumulating number of
studies reported that the prevalence of pediatric obesity and asthma might be altered …

Genetic and epigenetic differentiation in response to genomic selection for avian lay date

M Lindner, I Verhagen, AC Mateman… - Evolutionary …, 2024 - Wiley Online Library
Anthropogenic climate change has led to globally increasing temperatures at an
unprecedented pace and, to persist, wild species have to adapt to their changing world. We …

Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression

H Wright, CF Aylwin, CA Toro, SR Ojeda… - Scientific Reports, 2021 - nature.com
Female puberty is subject to Polycomb Group (PcG)-dependent transcriptional repression.
Kiss1, a puberty-activating gene, is a key target of this silencing mechanism. Using a gain-of …

Emerging applications of metabolomics to assess the efficacy of traditional Chinese medicines for treating type 2 diabetes mellitus

Y Zhang, Y Yang, L Ding, Z Wang, Y Xiao… - Frontiers in …, 2021 - frontiersin.org
Diabetes is a common and complex disease that can exacerbate the complications related
to cardiovascular disease, and this is especially true for type 2 diabetes mellitus (T2DM). In …

Lin28 gene and mammalian puberty

G Cao, Z Gao, Y Jiang, M Chu - Molecular Reproduction and …, 2020 - Wiley Online Library
Lin28a and Lin28b, homologs of the Caenorhabditis elegans Lin28 gene, play important
roles in cell pluripotency, reprogramming, and tumorigenicity. Recently, genome‐wide …