Ferroptosis is an iron-and lipid reactive oxygen species (ROS)-dependent form of
programmed cell death that is distinct from other forms of regulatory cell death at the …

Ferroptosis is a new mode of cell death different from cell necrosis, autophagy, apoptosis,
and pyroptosis, which depends on the accumulation of reactive oxygen species (ROS) …

Doxorubicin (Dox) is a high-efficiency agent for cancer therapy. However, it causes
cardiotoxicity which limits its clinical application. Despite more efforts has been made to …

Ferroptosis is a new form of regulated cell death resulting from the accumulation of lipid-
reactive oxygen species. A growing number of studies indicate ferroptosis as an important …

The prognosis of renal cell carcinoma (RCC) remains poor due to metastases and
resistance to chemotherapy. Salinomycin (Sal) exhibits the potential of antitumor, while the …

Recurrent breast cancer presents significant challenges with aggressive phenotypes and
treatment resistance. Therefore, novel therapeutics are urgently needed. Here, we report …

Ferroptosis, an iron-dependent form of non-apoptotic cell death, is believed to strongly
contribute to the pathogenesis of multiple cancers. Recently, the positive association …

Exposure of tumor cells to ionizing radiation (IR) alters the microenvironment, particularly the
fatty acid (FA) profile and activity. Moreover, abnormal FA metabolism, either catabolism or …

Ferroptosis refers to iron-dependent, specialized, and regulated-necrosis mediated by lipid
peroxidation, which is closely related to a variety of diseases, including cancer. Tumor cells …

Significance: The significance of ferroptosis in cancer therapeutics has now been unveiled.
Specific ferroptosis inducers are expected as a promising strategy for cancer treatment …