Phosphodiesterases (PDEs), enzymes that degrade 3′, 5′-cyclic nucleotides, are being
pursued as therapeutic targets for several diseases, including those affecting the nervous …

The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

Dendritic spines are the major sites of synaptic transmission in the central nervous system.
Alterations in the strength of synaptic connections directly affect the neuronal …

Phosphodiesterases (PDE) are a diverse family of enzymes (11 isoforms so far identified)
responsible for the degradation of cyclic adenosine monophosphate (cAMP) and cyclic …

Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and
asthma, affect millions of people all over the world. Cyclic adenosine monophosphate …

Highlights•Restoring hippocampal cAMP levels prevents sleep deprivation-induced memory
deficits.•Blocking hippocampal PDE4A5 function prevents memory deficits caused by sleep …

Neuroinflammatory disorders preferentially impair the higher cognitive and executive
functions of the prefrontal cortex (PFC). This includes such challenging disorders as …

Sleep and sleep loss have a profound impact on hippocampal function, leading to memory
impairments. Modifications in the strength of synaptic connections directly influences …

The regulation of neurons by circadian clock genes is thought to contribute to the
maintenance of neuronal functions that ultimately underlie animal behavior. However, the …

Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that envelop neurons
and regulate synaptic functions. Long thought to be stable structures, PNNs have been …