This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Pancreatic β-cells perform glucose-stimulated insulin secretion, a process at the center of
type 2 diabetes etiology. Efforts to understand how β-cells behave in healthy and stressful …

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is
characterized by dysfunction of insulin-producing pancreatic islet β cells1, 2. T2D genome …

Islet gene expression has been widely studied to better understand the transcriptional
features that define a healthy β-cell. Transcriptomes of FACS-purified α-, β-, and δ-cells …

Pancreatic islets of Langerhans play a pivotal role in regulating blood glucose homeostasis,
but critical information regarding their mass, distribution and composition is lacking within a …

Studies on diabetes have long been hampered by a lack of authentic disease models that,
ideally, should be unlimited and able to recapitulate the abnormalities involved in the …

Diabetes is a major health issue of increasing prevalence. ß‐cell replacement, by pancreas
or islet transplantation, is the only long‐term curative option for patients with insulin …

Obesity is the major contributing factor for the increased prevalence of type 2 diabetes (T2D)
in recent years. Sustained positive influx of lipids is considered to be a precipitating factor for …

Human allogeneic islet transplantation (ITx) is emerging as a promising treatment option for
qualified patients with type 1 diabetes. However, widespread clinical application of …

Over the last two decades, increased availability of human pancreatic tissues has allowed
for major expansions in our understanding of islet biology in health and disease. Indeed …