[HTML][HTML] Biomaterials from the sea: Future building blocks for biomedical applications

M Wan, W Qin, C Lei, Q Li, M Meng, M Fang, W Song… - Bioactive Materials, 2021 - Elsevier
Marine resources have tremendous potential for developing high-value biomaterials. The
last decade has seen an increasing number of biomaterials that originate from marine …

TROPHY-U-01: a phase II open-label study of sacituzumab govitecan in patients with metastatic urothelial carcinoma progressing after platinum-based chemotherapy …

ST Tagawa, AV Balar, DP Petrylak… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Patients with metastatic urothelial carcinoma (mUC) who progress on platinum-
based combination chemotherapy (PLT) and checkpoint inhibitors (CPIs) have limited …

Immunotherapy for bladder cancer: latest advances and ongoing clinical trials

DF Ward Grados, H Ahmadi, TS Griffith… - Immunological …, 2022 - Taylor & Francis
For nearly 50 years, immunotherapy has been used in patients with bladder cancer in the
form of Mycobacterium bovis Bacillus Calmette-Guerin (BCG), which is still the first-line …

Novel combination therapies for the treatment of bladder cancer

M Peng, D Xiao, Y Bu, J Long, X Yang, S Lv… - Frontiers in …, 2021 - frontiersin.org
Bladder cancer is the ninth most frequently diagnosed cancer world-wide and ranks 13th in
cancer-related deaths. Two tremendous breakthroughs in bladder cancer therapy over the …

Targeted molecular therapeutics for bladder cancer—a new option beyond the mixed fortunes of immune checkpoint inhibitors?

O Bednova, JV Leyton - International journal of molecular sciences, 2020 - mdpi.com
The fact that there are now five immune checkpoint inhibitor (ICI) monoclonal antibodies
approved since 2016 that target programmed cell death protein 1 or programmed death …

Antibody-drug conjugates in urothelial cancer: from scientific rationale to clinical development

WA Kwon, SY Lee, TY Jeong, HH Kim, MK Lee - Cancers, 2024 - mdpi.com
Simple Summary For metastatic urothelial cancer (UC), platinum-based chemotherapy and
immunotherapy are used, with newer treatments like monoclonal antibodies (eg …

Development of novel aptamer-based targeted chemotherapy for bladder cancer

Y Wang, Y Zhang, PC Li, J Guo, F Huo, J Yang, R Jia… - Cancer research, 2022 - AACR
Bladder cancer is common worldwide, with most patients presenting with nonmuscle
invasive disease. Multiple intravesical recurrences lead to reduced quality of life and high …

Extending traditional antibody therapies: Novel discoveries in immunotherapy and clinical applications

C Shin, SS Kim, YH Jo - Molecular Therapy-Oncolytics, 2021 - cell.com
Immunotherapy has been well regarded as one of the safer and antigen-specific anti-cancer
treatments compared to first-generation chemotherapy. Since Coley's discovery, researchers …

Antibody-drug conjugate targets, drugs, and linkers

BA Teicher, J Morris - Current Cancer Drug Targets, 2022 - ingentaconnect.com
Antibody-drug conjugates offer the possibility of directing powerful cytotoxic agents to a
malignant tumor while sparing normal tissue. The challenge is to select an antibody target …

Importance and considerations of antibody engineering in antibody-drug conjugates development from a clinical pharmacologist's perspective

AT Lucas, A Moody, AN Schorzman, WC Zamboni - Antibodies, 2021 - mdpi.com
Antibody-drug conjugates (ADCs) appear to be in a developmental boom, with five FDA
approvals in the last two years and a projected market value of over $4 billion by 2024 …