Biomarkers-guided precision therapeutics has revolutionized the clinical development and
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …

Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the
tumor by interfering with specific molecular targets and are currently the focus of anticancer …

The phosphatidylinositol 3-kinase (PI3K) signaling axis impacts on cancer cell growth,
survival, motility, and metabolism. This pathway is activated by several different mechanisms …

Introduction: The RAS/RAF/MAP kinase–ERK kinase (MEK)/extracellular-signal-regulated
kinase (ERK)(MAPK) and the PI3K/AKT/mammalian target of rapamycin (mTOR)(PI3K) …

We demonstrate that phosphatidylinositol 3-kinase (PI3K) pathway aberrations occur in>
80% of endometrioid endometrial cancers, with coordinate mutations of multiple PI3K …

Endometrial cancer is the most common gynecologic malignancy in the United States.
Overactivation of the PI3K/AKT/mTOR pathway, a signaling pathway that plays an important …

In the past decade, there has been a resurgence of interest in elucidating how metabolism is
altered in cancer cells and how such dependencies can be targeted for therapeutic gain. At …

Endometrial cancer is the most common gynecological malignancy, with more than 280,000
cases occurring annually worldwide. Although previous studies have identified important …

The serine/threonine kinase Akt, also known as protein kinase B (PKB), is one of the key
factors regulating glucose and lipid energy metabolism, and is the core focus of current …