HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …

The selective 5-HT2C receptor agonist lorcaserin, in conjunction with lifestyle modification,
was approved by the FDA in 2012 for weight management. It has been marketed in the US …

Despite the availability of over 30 antiseizure medications (ASMs), there is no “one size fits it
all,” so there is a continuing search for novel ASMs. There are divergent data demonstrating …

The constitutive activity of different serotonin receptors (5-HTRs) toward intracellular
signaling pathways has been proposed to have physiological and pathological importance …

This paper is a personal account on the discovery and characterization of the 5-HT 2C
receptor (first known as the 5-HT 1C receptor) over 30 years ago and how it translated into a …

A large body of experimental and clinical evidence has strongly suggested that monoamines
play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and …

ABSTRACT Introduction Developmental epileptic encephalopathies (DEEs) pose significant
challenges due to their refractory nature and limited treatment options. Despite …

Purpose of review Dravet syndrome is a rare but severe genetic epilepsy that has unique
treatment challenges. This is a review of current and future potential treatment options …

Abstract Endocannabinoid (eCB) and serotonin (5-HT) neuromodulatory systems work both
independently and together to finely orchestrate neuronal activity throughout the brain to …