Macrophage dysfunction has been well-described in Cystic Fibrosis (CF) and may contribute
to bacterial persistence in the lung. Whether CF macrophage dysfunction is related directly …

Cystic fibrosis (CF) causes life-shortening respiratory and systemic disease due to
dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride …

The lungs of people with cystic fibrosis (PwCF) are characterized by recurrent bacterial
infections and inflammation. Infections in cystic fibrosis (CF) are left unresolved despite …

Cystic fibrosis in the era of CFTR modulators: did the neutrophil slip through the cracks? Page
1 Cystic fibrosis in the era of CFTR modulators: did the neutrophil slip through the cracks …

Immune cells express a variety of ion channels and transporters in the plasma membrane
and intracellular organelles, responsible of the transference of charged ions across …

Inflammation is a key driver in the pathogenesis of cystic fibrosis (CF). We assessed the
effectiveness of elexacaftor/tezacaftor/ivacaftor (ETI) therapy on downregulating systemic …

Extract Cystic fibrosis (CF) is caused by an absence or dysfunction of the transmembrane
conductance regulator (CFTR) protein, an anion channel exchanging chloride and …

Cystic fibrosis (CF) is a genetic disorder caused by mutations in the chloride channel cystic
fibrosis transmembrane conductance regulator (CFTR). The defective ion transport causes …